Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
BF49_0080Phosphopantothenoylcysteine decarboxylase EC 41136 Phosphopantothenoylcysteine synthetase EC 6325; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (488 aa)    
Predicted Functional Partners:
coaD
Phosphopantetheine adenylyltransferase EC 2773; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
 
 
 0.995
dut
Deoxyuridine 5triphosphate nucleotidohydrolase EC 36123; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
 
 
 0.988
coaA
Pantothenate kinase EC 27133.
  
 
 0.976
panC
Pantoatebetaalanine ligase EC 6321; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
 
  
 0.901
BF49_7015
Nucleoside triphosphate pyrophosphohydrolase MazG EC 3618.
     
  0.900
BF49_2942
Aspartate aminotransferase EC 2611.
 
 0.864
vapC-2
VapC toxin protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family.
   
 
 0.859
BF49_6845
Cysteine synthase EC 25147; Belongs to the cysteine synthase/cystathionine beta- synthase family.
    
 0.843
coaE
DephosphoCoA kinase EC 27124; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
 
 
 0.837
BF49_0544
Cysteine synthase EC 25147.
    
 0.828
Your Current Organism:
Bradyrhizobium sp.
NCBI taxonomy Id: 376
Other names: B. sp.
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