Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
BF49_0088FIG149041 Thioredoxin; Belongs to the thioredoxin family. (106 aa)    
Predicted Functional Partners:
BF49_2893
Thioredoxin reductase EC 1819.
 
 0.984
BF49_6388
Thioredoxin reductase EC 1819.
 
 
 0.844
BF49_5758
Thioredoxin reductase EC 1819.
  
 
 0.815
groL
Heat shock protein 60 family chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 
 0.767
groL-2
Heat shock protein 60 family chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 
 0.767
BF49_4258
Phosphoadenylylsulfate reductase thioredoxin EC 1848 Adenylylsulfate reductase thioredoxin EC 18410; Reduction of activated sulfate into sulfite.
    
 
 0.763
BF49_0774
Ribonucleotide reductase of class II coenzyme B12dependent EC 11741; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
  
 
 0.747
grpE
Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]
 
  
 0.745
BF49_1604
Arsenate reductase EC 12041; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
  
 
 0.734
BF49_0087
FIG061771 ATPdependent nuclease subunit A; Belongs to the helicase family. UvrD subfamily.
       0.732
Your Current Organism:
Bradyrhizobium sp.
NCBI taxonomy Id: 376
Other names: B. sp.
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