Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mdhMalate dehydrogenase EC 11137; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (322 aa)    
Predicted Functional Partners:
BF49_0597
Citrate synthase si EC 2331; Belongs to the citrate synthase family.
  
 0.999
BF49_0598
Citrate synthase si EC 2331.
  
 0.999
BF49_5845
Fumarate hydratase class I aerobic EC 4212; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.999
BF49_6722
Citrate synthase si EC 2331; Belongs to the citrate synthase family.
  
 0.999
fumC
Fumarate hydratase class II EC 4212; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.998
pckA
Phosphoenolpyruvate carboxykinase ATP EC 41149; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
 
 
 0.994
glcB
Malate synthase G EC 2339; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
   
 0.993
ppc
Phosphoenolpyruvate carboxylase EC 41131; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family.
   
 
 0.992
BF49_0917
NADdependent malic enzyme EC 11138.
 
 0.985
BF49_5890
Isocitrate dehydrogenase NADP EC 11142; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
 0.975
Your Current Organism:
Bradyrhizobium sp.
NCBI taxonomy Id: 376
Other names: B. sp.
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