Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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Score
sucCSuccinylCoA ligase ADPforming beta chain EC 6215; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (398 aa)    
Predicted Functional Partners:
sucD
SuccinylCoA ligase ADPforming alpha chain EC 6215; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.999
BF49_0406
2oxoglutarate dehydrogenase E1 component EC 1242.
 
 0.998
BF49_0408
Dihydrolipoamide succinyltransferase component E2 of 2oxoglutarate dehydrogenase complex EC 23161; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
 0.998
BF49_0337
Succinate dehydrogenase ironsulfur protein EC 13991; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
 
 0.996
BF49_0340
Succinate dehydrogenase cytochrome b556 subunit.
  
 
 0.996
BF49_0338
Succinate dehydrogenase flavoprotein subunit EC 13991; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 
 0.994
BF49_0339
Succinate dehydrogenase hydrophobic membrane anchor protein.
  
 
 0.994
BF49_5283
Succinate dehydrogenase ironsulfur protein EC 13991.
 
 0.994
BF49_6762
Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.989
BF49_4909
2oxoglutarate oxidoreductase alpha subunit EC 1273.
    
 0.983
Your Current Organism:
Bradyrhizobium sp.
NCBI taxonomy Id: 376
Other names: B. sp.
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