STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BF49_04062oxoglutarate dehydrogenase E1 component EC 1242. (989 aa)    
Predicted Functional Partners:
BF49_0408
Dihydrolipoamide succinyltransferase component E2 of 2oxoglutarate dehydrogenase complex EC 23161; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 0.999
BF49_0410
Dihydrolipoamide dehydrogenase of 2oxoglutarate dehydrogenase EC 1814.
 
 0.999
sucC
SuccinylCoA ligase ADPforming beta chain EC 6215; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.998
sucD
SuccinylCoA ligase ADPforming alpha chain EC 6215; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.998
BF49_5890
Isocitrate dehydrogenase NADP EC 11142; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
 0.998
BF49_6764
Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex EC 1814.
 
 0.998
BF49_6762
Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.990
BF49_6759
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 
 0.989
BF49_1808
FIG00444077 hypothetical protein.
  
 0.964
BF49_5941
FIG00446651 hypothetical protein.
  
 0.964
Your Current Organism:
Bradyrhizobium sp.
NCBI taxonomy Id: 376
Other names: B. sp.
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.