Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
proBGlutamate 5kinase EC 27211 RNAbinding Cterminal domain PUA; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (373 aa)    
Predicted Functional Partners:
proA
Gammaglutamyl phosphate reductase EC 12141; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
 
 0.999
BF49_3171
Glutamate synthase NADPH large chain EC 14113.
    
 0.958
BF49_2793
Proline dehydrogenase EC 15998 Proline oxidase Delta1pyrroline5carboxylate dehydrogenase EC 15112; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
   
 0.946
guaA
GMP synthase glutaminehydrolyzing EC 6352; Catalyzes the synthesis of GMP from XMP.
  
 
 0.943
BF49_1681
Acetylornithine aminotransferase EC 26111; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
   
 0.940
pyrG
CTP synthase EC 6342; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
   
 0.929
carB
Carbamoylphosphate synthase large chain EC 6355; Belongs to the CarB family.
    
 0.918
hisF
Imidazole glycerol phosphate synthase cyclase subunit EC 413; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
 
 0.901
carA
Carbamoylphosphate synthase small chain EC 6355; Belongs to the CarA family.
    
  0.897
hisH
Imidazole glycerol phosphate synthase amidotransferase subunit EC 242; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
     
  0.894
Your Current Organism:
Bradyrhizobium sp.
NCBI taxonomy Id: 376
Other names: B. sp.
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