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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glnEGlutamateammonialigase adenylyltransferase EC 27742; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal [...] (995 aa)    
Predicted Functional Partners:
glnD
ProteinPII uridylyltransferase EC 27759; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
 
   
 0.877
BF49_1554
Sensor protein basSpmrB EC 273.
     
 0.809
BF49_1555
Response regulator in twocomponent regulatory system with PhoQ.
     
 0.809
BF49_3171
Glutamate synthase NADPH large chain EC 14113.
    
 0.782
BF49_6608
Glutamine synthetase type I EC 6312.
 
  
 0.760
BF49_0734
Thiol peroxidase Bcptype EC 111115.
     0.664
BF49_2142
Twocomponent hybrid sensor and regulator.
     
 0.474
BF49_6609
Nitrogen regulatory protein PII; Belongs to the P(II) protein family.
 
 
 
 0.444
BF49_1556
Serine protease precursor MucDAlgY associated with sigma factor RpoE; Belongs to the peptidase S1C family.
  
  
 0.442
BF49_4910
Glutamate synthase NADPH small chain EC 14113.
    
 0.428
Your Current Organism:
Bradyrhizobium sp.
NCBI taxonomy Id: 376
Other names: B. sp.
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