STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BF49_1580Acetolactate synthase large subunit EC 2216; Belongs to the TPP enzyme family. (544 aa)    
Predicted Functional Partners:
BF49_5173
Acetolactate synthase small subunit EC 2216.
 
 0.958
ilvC
Ketolacid reductoisomerase EC 11186; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.912
ilvD
Dihydroxyacid dehydratase EC 4219; Belongs to the IlvD/Edd family.
  
 0.809
ilvD-2
Dihydroxyacid dehydratase EC 4219; Belongs to the IlvD/Edd family.
  
 0.789
BF49_1857
Dihydroxyacid dehydratase EC 4219; Belongs to the IlvD/Edd family.
 
  
 0.726
BF49_0468
Dihydroxyacid dehydratase EC 4219; Belongs to the IlvD/Edd family.
 
  
 0.692
BF49_0917
NADdependent malic enzyme EC 11138.
  
 
 0.671
BF49_6805
Threonine dehydratase EC 43119.
  
 0.669
BF49_4909
2oxoglutarate oxidoreductase alpha subunit EC 1273.
 
 
 0.665
ilvD-3
Dihydroxyacid dehydratase EC 4219; Belongs to the IlvD/Edd family.
 
  
 0.651
Your Current Organism:
Bradyrhizobium sp.
NCBI taxonomy Id: 376
Other names: B. sp.
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.