| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BF49_0091 | BF49_0169 | BF49_0091 | BF49_0169 | Dihydrofolate synthase EC 63212 Folylpolyglutamate synthase EC 63217; Belongs to the folylpolyglutamate synthase family. | Nucleoside 5triphosphatase RdgB dHAPTP dITP XTPspecific EC 36115; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.547 |
| BF49_0091 | BF49_1631 | BF49_0091 | BF49_1631 | Dihydrofolate synthase EC 63212 Folylpolyglutamate synthase EC 63217; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase EC 25115; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.999 |
| BF49_0091 | BF49_1632 | BF49_0091 | BF49_1632 | Dihydrofolate synthase EC 63212 Folylpolyglutamate synthase EC 63217; Belongs to the folylpolyglutamate synthase family. | Dihydroneopterin aldolase EC 41225; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.862 |
| BF49_0091 | BF49_1633 | BF49_0091 | BF49_1633 | Dihydrofolate synthase EC 63212 Folylpolyglutamate synthase EC 63217; Belongs to the folylpolyglutamate synthase family. | 2amino4hydroxy6 hydroxymethyldihydropteridine pyrophosphokinase EC 2763. | 0.899 |
| BF49_0091 | BF49_3435 | BF49_0091 | BF49_3435 | Dihydrofolate synthase EC 63212 Folylpolyglutamate synthase EC 63217; Belongs to the folylpolyglutamate synthase family. | Protein RcsF. | 0.429 |
| BF49_0091 | BF49_6546 | BF49_0091 | BF49_6546 | Dihydrofolate synthase EC 63212 Folylpolyglutamate synthase EC 63217; Belongs to the folylpolyglutamate synthase family. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.788 |
| BF49_0091 | folE | BF49_0091 | BF49_1709 | Dihydrofolate synthase EC 63212 Folylpolyglutamate synthase EC 63217; Belongs to the folylpolyglutamate synthase family. | GTP cyclohydrolase I EC 35416 type 1. | 0.673 |
| BF49_0091 | folE-2 | BF49_0091 | BF49_6119 | Dihydrofolate synthase EC 63212 Folylpolyglutamate synthase EC 63217; Belongs to the folylpolyglutamate synthase family. | GTP cyclohydrolase I EC 35416 type 1. | 0.673 |
| BF49_0169 | BF49_0091 | BF49_0169 | BF49_0091 | Nucleoside 5triphosphatase RdgB dHAPTP dITP XTPspecific EC 36115; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Dihydrofolate synthase EC 63212 Folylpolyglutamate synthase EC 63217; Belongs to the folylpolyglutamate synthase family. | 0.547 |
| BF49_0169 | BF49_1631 | BF49_0169 | BF49_1631 | Nucleoside 5triphosphatase RdgB dHAPTP dITP XTPspecific EC 36115; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Dihydropteroate synthase EC 25115; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.646 |
| BF49_0169 | BF49_1632 | BF49_0169 | BF49_1632 | Nucleoside 5triphosphatase RdgB dHAPTP dITP XTPspecific EC 36115; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Dihydroneopterin aldolase EC 41225; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.652 |
| BF49_0169 | BF49_1633 | BF49_0169 | BF49_1633 | Nucleoside 5triphosphatase RdgB dHAPTP dITP XTPspecific EC 36115; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 2amino4hydroxy6 hydroxymethyldihydropteridine pyrophosphokinase EC 2763. | 0.648 |
| BF49_0169 | folE | BF49_0169 | BF49_1709 | Nucleoside 5triphosphatase RdgB dHAPTP dITP XTPspecific EC 36115; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GTP cyclohydrolase I EC 35416 type 1. | 0.642 |
| BF49_0169 | folE-2 | BF49_0169 | BF49_6119 | Nucleoside 5triphosphatase RdgB dHAPTP dITP XTPspecific EC 36115; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GTP cyclohydrolase I EC 35416 type 1. | 0.642 |
| BF49_0313 | BF49_1632 | BF49_0313 | BF49_1632 | Secreted alkaline phosphatase. | Dihydroneopterin aldolase EC 41225; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.907 |
| BF49_0313 | BF49_2122 | BF49_0313 | BF49_2122 | Secreted alkaline phosphatase. | Secreted alkaline phosphatase. | 0.905 |
| BF49_0313 | folE | BF49_0313 | BF49_1709 | Secreted alkaline phosphatase. | GTP cyclohydrolase I EC 35416 type 1. | 0.916 |
| BF49_0313 | folE-2 | BF49_0313 | BF49_6119 | Secreted alkaline phosphatase. | GTP cyclohydrolase I EC 35416 type 1. | 0.916 |
| BF49_1631 | BF49_0091 | BF49_1631 | BF49_0091 | Dihydropteroate synthase EC 25115; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Dihydrofolate synthase EC 63212 Folylpolyglutamate synthase EC 63217; Belongs to the folylpolyglutamate synthase family. | 0.999 |
| BF49_1631 | BF49_0169 | BF49_1631 | BF49_0169 | Dihydropteroate synthase EC 25115; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Nucleoside 5triphosphatase RdgB dHAPTP dITP XTPspecific EC 36115; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.646 |