STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Coexpression
Experiments
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[Homology]
Score
BF49_2234COG1896 Predicted hydrolases of HD superfamily. (195 aa)    
Predicted Functional Partners:
surE
5nucleotidase SurE EC 3135; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.925
dut
Deoxyuridine 5triphosphate nucleotidohydrolase EC 36123; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
  
 
 0.916
BF49_0775
Deoxyguanosinetriphosphate triphosphohydrolase EC 3151.
  
 
  0.914
BF49_6784
Deoxyguanosinetriphosphate triphosphohydrolase EC 3151; Belongs to the dGTPase family. Type 2 subfamily.
  
 
  0.914
BF49_2072
5nucleotidase EC 3135; Belongs to the 5'-nucleotidase family.
    
 0.909
tmk
Thymidylate kinase EC 2749; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
    
 0.906
thyA
Thymidylate synthase EC 21145; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
    
 0.905
cmk
Cytidylate kinase EC 27425.
     
 0.904
BF49_1575
Thymidine phosphorylase EC 2424.
    
  0.903
gmk
Guanylate kinase EC 2748; Essential for recycling GMP and indirectly, cGMP.
   
 
  0.902
Your Current Organism:
Bradyrhizobium sp.
NCBI taxonomy Id: 376
Other names: B. sp.
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