STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aptAdenine phosphoribosyltransferase EC 2427; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (179 aa)    
Predicted Functional Partners:
guaA
GMP synthase glutaminehydrolyzing EC 6352; Catalyzes the synthesis of GMP from XMP.
  
 0.988
gmk
Guanylate kinase EC 2748; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.979
ade
Adenine deaminase EC 3542; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
    
 0.978
purH
IMP cyclohydrolase EC 35410 Phosphoribosylaminoimidazolecarboxamide formyltransferase EC 2123.
  
 0.963
adk
Adenylate kinase EC 2743 histone protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
  
 
 0.961
amn
AMP nucleosidase EC 3224; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.
   
 0.953
BF49_5952
Adenylosuccinate lyase EC 4322; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.951
mtnP
5methylthioadenosine phosphorylase EC 24228; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
 
 0.944
gpt
Xanthineguanine phosphoribosyltransferase EC 24222; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
  
 
 0.942
BF49_0297
GMP synthase glutaminehydrolyzing EC 6352.
  
 
 0.932
Your Current Organism:
Bradyrhizobium sp.
NCBI taxonomy Id: 376
Other names: B. sp.
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