| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BF49_1631 | BF49_1633 | BF49_1631 | BF49_1633 | Dihydropteroate synthase EC 25115; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 2amino4hydroxy6 hydroxymethyldihydropteridine pyrophosphokinase EC 2763. | 0.999 |
| BF49_1631 | BF49_2303 | BF49_1631 | BF49_2303 | Dihydropteroate synthase EC 25115; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Anthranilate synthase aminase component EC 41327 Anthranilate synthase amidotransferase component EC 41327. | 0.959 |
| BF49_1631 | aroE | BF49_1631 | BF49_2936 | Dihydropteroate synthase EC 25115; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Shikimate 5dehydrogenase I alpha EC 11125; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.486 |
| BF49_1633 | BF49_1631 | BF49_1633 | BF49_1631 | 2amino4hydroxy6 hydroxymethyldihydropteridine pyrophosphokinase EC 2763. | Dihydropteroate synthase EC 25115; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.999 |
| BF49_1633 | BF49_2303 | BF49_1633 | BF49_2303 | 2amino4hydroxy6 hydroxymethyldihydropteridine pyrophosphokinase EC 2763. | Anthranilate synthase aminase component EC 41327 Anthranilate synthase amidotransferase component EC 41327. | 0.865 |
| BF49_2303 | BF49_1631 | BF49_2303 | BF49_1631 | Anthranilate synthase aminase component EC 41327 Anthranilate synthase amidotransferase component EC 41327. | Dihydropteroate synthase EC 25115; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.959 |
| BF49_2303 | BF49_1633 | BF49_2303 | BF49_1633 | Anthranilate synthase aminase component EC 41327 Anthranilate synthase amidotransferase component EC 41327. | 2amino4hydroxy6 hydroxymethyldihydropteridine pyrophosphokinase EC 2763. | 0.865 |
| BF49_2303 | apt | BF49_2303 | BF49_2302 | Anthranilate synthase aminase component EC 41327 Anthranilate synthase amidotransferase component EC 41327. | Adenine phosphoribosyltransferase EC 2427; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.874 |
| BF49_2303 | aroC | BF49_2303 | BF49_2093 | Anthranilate synthase aminase component EC 41327 Anthranilate synthase amidotransferase component EC 41327. | Chorismate synthase EC 4235; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.994 |
| BF49_2303 | aroE | BF49_2303 | BF49_2936 | Anthranilate synthase aminase component EC 41327 Anthranilate synthase amidotransferase component EC 41327. | Shikimate 5dehydrogenase I alpha EC 11125; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.902 |
| BF49_2303 | trpA | BF49_2303 | BF49_0093 | Anthranilate synthase aminase component EC 41327 Anthranilate synthase amidotransferase component EC 41327. | Tryptophan synthase alpha chain EC 42120; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.977 |
| BF49_2303 | trpB | BF49_2303 | BF49_0094 | Anthranilate synthase aminase component EC 41327 Anthranilate synthase amidotransferase component EC 41327. | Tryptophan synthase beta chain EC 42120; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.985 |
| BF49_2303 | trpC | BF49_2303 | BF49_6736 | Anthranilate synthase aminase component EC 41327 Anthranilate synthase amidotransferase component EC 41327. | Indole3glycerol phosphate synthase EC 41148; Belongs to the TrpC family. | 0.999 |
| BF49_2303 | trpD | BF49_2303 | BF49_6737 | Anthranilate synthase aminase component EC 41327 Anthranilate synthase amidotransferase component EC 41327. | Anthranilate phosphoribosyltransferase EC 24218; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
| BF49_2303 | trpF | BF49_2303 | BF49_0095 | Anthranilate synthase aminase component EC 41327 Anthranilate synthase amidotransferase component EC 41327. | Phosphoribosylanthranilate isomerase EC 53124; Belongs to the TrpF family. | 0.988 |
| apt | BF49_2303 | BF49_2302 | BF49_2303 | Adenine phosphoribosyltransferase EC 2427; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Anthranilate synthase aminase component EC 41327 Anthranilate synthase amidotransferase component EC 41327. | 0.874 |
| aroC | BF49_2303 | BF49_2093 | BF49_2303 | Chorismate synthase EC 4235; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate synthase aminase component EC 41327 Anthranilate synthase amidotransferase component EC 41327. | 0.994 |
| aroC | aroE | BF49_2093 | BF49_2936 | Chorismate synthase EC 4235; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Shikimate 5dehydrogenase I alpha EC 11125; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.947 |
| aroC | trpA | BF49_2093 | BF49_0093 | Chorismate synthase EC 4235; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Tryptophan synthase alpha chain EC 42120; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.907 |
| aroC | trpB | BF49_2093 | BF49_0094 | Chorismate synthase EC 4235; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Tryptophan synthase beta chain EC 42120; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.818 |