Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hisSHistidyltRNA synthetase EC 61121. (509 aa)    
Predicted Functional Partners:
hisG
ATP phosphoribosyltransferase EC 24217; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
 0.964
aspS
AspartyltRNA synthetase EC 61112 AspartyltRNAAsn synthetase EC 61123; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
 
  
 0.912
thrS
ThreonyltRNA synthetase EC 6113; Belongs to the class-II aminoacyl-tRNA synthetase family.
 
 
 0.881
glyQ
GlycyltRNA synthetase alpha chain EC 61114.
  
  
 0.861
cysS
CysteinyltRNA synthetase EC 61116; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.849
ispG
1hydroxy2methyl2Ebutenyl 4diphosphate synthase EC 11771; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.
  
  
 0.818
leuS
LeucyltRNA synthetase EC 6114; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.790
ftsA
Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family.
  
    0.783
BF49_3057
ATP phosphoribosyltransferase regulatory subunit EC 24217.
  
 0.773
tyrS
TyrosyltRNA synthetase EC 6111; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
  
 
 0.761
Your Current Organism:
Bradyrhizobium sp.
NCBI taxonomy Id: 376
Other names: B. sp.
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