Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
lpxKTetraacyldisaccharide 4kinase EC 271130; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (338 aa)    
Predicted Functional Partners:
BF49_3045
Lipid IVA 3deoxyDmannooctulosonic acid transferase EC 249912 often with EC 249913 also; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
 
 0.999
lpxB
LipidAdisaccharide synthase EC 241182; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
  
 0.993
BF49_3046
Protein of unknown function DUF374.
 
     0.935
BF49_3174
Polysialic acid capsule sugar isomerase KpsFGutQ family; Belongs to the SIS family. GutQ/KpsF subfamily.
 
   
 0.897
BF49_6713
AcylacylcarrierproteinUDPN acetylglucosamine Oacyltransferase EC 231129; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
   
 0.888
lpxC
UDP3O3hydroxymyristoyl Nacetylglucosamine deacetylase EC 351108; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family.
 
   
 0.878
lpxD
UDP3O3hydroxymyristoyl glucosamine Nacyltransferase EC 231191; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
 
   
 0.873
kdsA
2Keto3deoxyDmannooctulosonate8phosphate synthase EC 25155; Belongs to the KdsA family.
 
   
 0.866
kdsB
3deoxymannooctulosonate cytidylyltransferase EC 27738; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
 
   
 0.860
BF49_3047
Uncharacterized protein Bsl7517 homolog.
     
 0.858
Your Current Organism:
Bradyrhizobium sp.
NCBI taxonomy Id: 376
Other names: B. sp.
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