Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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cobB-2NADdependent protein deacetylase of SIR2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. (253 aa)    
Predicted Functional Partners:
nadE
NAD synthetase EC 6315 Glutamine amidotransferase chain of NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.934
nadE-2
NAD synthetase EC 6315 Glutamine amidotransferase chain of NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.934
BF49_3498
NADH pyrophosphatase EC 36122.
  
  0.924
nadD
Nicotinatenucleotide adenylyltransferase EC 27718; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
   
 0.922
nadK
NAD kinase EC 27123; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.917
BF49_0165
Nicotinamidase EC 35119.
   
 0.916
BF49_6946
Nicotinamidase EC 35119.
   
 0.916
BF49_4404
NADP transhydrogenase alpha subunit EC 1612.
     
 0.905
BF49_4405
NADP transhydrogenase alpha subunit EC 1612.
     
 0.904
BF49_4406
NADP transhydrogenase subunit beta EC 1612; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
    
  0.902
Your Current Organism:
Bradyrhizobium sp.
NCBI taxonomy Id: 376
Other names: B. sp.
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