Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
gene fusions
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[Homology]
Score
BF49_3873DNA topoisomerase IB poxvirus type EC 59912. (367 aa)    
Predicted Functional Partners:
rnhB-2
Ribonuclease HII EC 31264; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
   
 
 0.822
BF49_0541
ATPdependent DNA helicase RecQ.
    
 
 0.747
BF49_5589
SerThr protein phosphatase family protein.
   
 
 0.725
parE
Topoisomerase IV subunit B EC 5991; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
   
 
 0.706
rnhB
Ribonuclease HII EC 31264; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
    
 
 0.694
gyrB
DNA gyrase subunit B EC 59913; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.693
BF49_7330
DNA gyrase subunit B EC 59913.
   
 
 0.693
BF49_7325
DNA polymerase III beta subunit EC 2777; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...]
    
 
 0.692
prfB
Peptide chain release factor 2 programmed frameshiftcontaining; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
    
   0.644
BF49_3025
Hypothetical protein YaeJ with similarity to translation release factor.
    
   0.644
Your Current Organism:
Bradyrhizobium sp.
NCBI taxonomy Id: 376
Other names: B. sp.
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