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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BF49_3873DNA topoisomerase IB poxvirus type EC 59912. (367 aa)    
Predicted Functional Partners:
rnhB-2
Ribonuclease HII EC 31264; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
   
 
 0.785
BF49_0541
ATPdependent DNA helicase RecQ.
    
 
 0.703
gyrB
DNA gyrase subunit B EC 59913; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.664
parE
Topoisomerase IV subunit B EC 5991; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
   
 
 0.664
BF49_7330
DNA gyrase subunit B EC 59913.
   
 
 0.664
rnhB
Ribonuclease HII EC 31264; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
    
 
 0.628
BF49_3871
ATPdependent DNA ligase EC 6511.
 
 
 
 0.624
BF49_4877
ATPdependent DNA ligase EC 6511 clustered with Ku protein LigD.
 
 
 
 0.573
BF49_3749
ATPdependent DNA ligase EC 6511 clustered with Ku protein LigD.
 
 
 
 0.565
BF49_3828
ATPdependent DNA ligase EC 6511 clustered with Ku protein LigD.
 
 
 
 0.542
Your Current Organism:
Bradyrhizobium sp.
NCBI taxonomy Id: 376
Other names: B. sp.
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