STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BF49_4254Siroheme synthase Precorrin2 oxidase EC 13176 Sirohydrochlorin ferrochelatase EC 49914; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (474 aa)    
Predicted Functional Partners:
BF49_1432
Cobaltprecorrin2 C20methyltransferase EC 211130; Belongs to the precorrin methyltransferase family.
  
 
 0.994
BF49_1425
UroporphyrinogenIII methyltransferase EC 211107; Belongs to the precorrin methyltransferase family.
 
 
0.993
BF49_4256
Sulfite reductase NADPH hemoprotein betacomponent EC 1812.
 
 
 0.991
BF49_4258
Phosphoadenylylsulfate reductase thioredoxin EC 1848 Adenylylsulfate reductase thioredoxin EC 18410; Reduction of activated sulfate into sulfite.
 
  
 0.989
BF49_2404
Porphobilinogen deaminase EC 25161; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.987
BF49_0274
UroporphyrinogenIII synthase EC 42175; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 
 0.986
BF49_5690
UroporphyrinogenIII methyltransferase EC 211107 UroporphyrinogenIII synthase EC 42175.
 
 
 0.982
cysC
Sulfate adenylyltransferase subunit 1 EC 2774 Adenylylsulfate kinase EC 27125; Catalyzes the synthesis of activated sulfate. Belongs to the APS kinase family.
 
  
 0.979
BF49_1429
Precorrin-6Y C5,15-methyltransferase (decarboxylating); Cobaltprecorrin6y C5methyltransferase EC 211 Cobaltprecorrin6y C15methyltransferase decarboxylating EC 211.
  
 
 0.978
hemE
Uroporphyrinogen III decarboxylase EC 41137; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.968
Your Current Organism:
Bradyrhizobium sp.
NCBI taxonomy Id: 376
Other names: B. sp.
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