close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAAdenylosuccinate synthetase EC 6344; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)    
Predicted Functional Partners:
BF49_5952
Adenylosuccinate lyase EC 4322; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
 0.999
purH
IMP cyclohydrolase EC 35410 Phosphoribosylaminoimidazolecarboxamide formyltransferase EC 2123.
 
 0.996
guaB
Inosine5monophosphate dehydrogenase EC 111205 CBS domain; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.993
pyrB
Aspartate carbamoyltransferase EC 2132; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
 
 0.962
guaA
GMP synthase glutaminehydrolyzing EC 6352; Catalyzes the synthesis of GMP from XMP.
 
  
 0.956
BF49_1527
3carboxyciscismuconate cycloisomerase EC 5512.
 
 0.938
BF49_5647
Asparagine synthetase glutaminehydrolyzing EC 6354.
  
 
 0.935
BF49_4053
3carboxyciscismuconate cycloisomerase EC 5512.
 
 0.934
argG
Argininosuccinate synthase EC 6345; Belongs to the argininosuccinate synthase family. Type 2 subfamily.
  
 
 0.933
BF49_2942
Aspartate aminotransferase EC 2611.
 
 0.929
Your Current Organism:
Bradyrhizobium sp.
NCBI taxonomy Id: 376
Other names: B. sp.
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.