close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BF49_4844Acetolactate synthase large subunit EC 2216; Belongs to the TPP enzyme family. (553 aa)    
Predicted Functional Partners:
ilvC
Ketolacid reductoisomerase EC 11186; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.982
BF49_4909
2oxoglutarate oxidoreductase alpha subunit EC 1273.
  
 
 0.959
BF49_1903
3isopropylmalate dehydrogenase EC 11185.
 
 0.952
leuB
3isopropylmalate dehydrogenase EC 11185; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.951
BF49_1775
Tartrate dehydrogenase EC 11193 Tartrate decarboxylase EC 41173 Dmalic enzyme EC 11183.
 
 0.950
BF49_1947
3isopropylmalate dehydrogenase EC 11185.
 
 0.950
BF49_5093
Tartrate dehydrogenase EC 11193 Tartrate decarboxylase EC 41173 Dmalic enzyme EC 11183.
 
 0.950
BF49_4908
2oxoglutarate oxidoreductase beta subunit EC 1273.
  
 
 0.937
BF49_0917
NADdependent malic enzyme EC 11138.
  
 
 0.931
BF49_5173
Acetolactate synthase small subunit EC 2216.
 
 0.926
Your Current Organism:
Bradyrhizobium sp.
NCBI taxonomy Id: 376
Other names: B. sp.
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.