| node1 | node2 | node1 annotation | node2 annotation | score |
| BF49_0563 | BF49_2686 | Aspartokinase EC 2724; Belongs to the aspartokinase family. | Osuccinylbenzoic acidCoA ligase EC 62126. | 0.688 |
| BF49_0563 | BF49_4254 | Aspartokinase EC 2724; Belongs to the aspartokinase family. | Siroheme synthase Precorrin2 oxidase EC 13176 Sirohydrochlorin ferrochelatase EC 49914; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.595 |
| BF49_0563 | BF49_5017 | Aspartokinase EC 2724; Belongs to the aspartokinase family. | Glutamate1semialdehyde21aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.750 |
| BF49_0563 | BF49_5673 | Aspartokinase EC 2724; Belongs to the aspartokinase family. | Glutamate1semialdehyde aminotransferase EC 5438; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.766 |
| BF49_0563 | BF49_6553 | Aspartokinase EC 2724; Belongs to the aspartokinase family. | Peptide synthetase; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.512 |
| BF49_2404 | BF49_4254 | Porphobilinogen deaminase EC 25161; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Siroheme synthase Precorrin2 oxidase EC 13176 Sirohydrochlorin ferrochelatase EC 49914; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.987 |
| BF49_2404 | BF49_5017 | Porphobilinogen deaminase EC 25161; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Glutamate1semialdehyde21aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.797 |
| BF49_2404 | BF49_5673 | Porphobilinogen deaminase EC 25161; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Glutamate1semialdehyde aminotransferase EC 5438; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.892 |
| BF49_2404 | BF49_6537 | Porphobilinogen deaminase EC 25161; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Porphobilinogen synthase EC 42124; Belongs to the ALAD family. | 0.997 |
| BF49_2404 | BF49_6538 | Porphobilinogen deaminase EC 25161; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Porphobilinogen synthase EC 42124; Belongs to the ALAD family. | 0.999 |
| BF49_2686 | BF49_0563 | Osuccinylbenzoic acidCoA ligase EC 62126. | Aspartokinase EC 2724; Belongs to the aspartokinase family. | 0.688 |
| BF49_2686 | BF49_4033 | Osuccinylbenzoic acidCoA ligase EC 62126. | 5aminolevulinate synthase EC 23137. | 0.524 |
| BF49_2686 | BF49_5017 | Osuccinylbenzoic acidCoA ligase EC 62126. | Glutamate1semialdehyde21aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.862 |
| BF49_2686 | BF49_5673 | Osuccinylbenzoic acidCoA ligase EC 62126. | Glutamate1semialdehyde aminotransferase EC 5438; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.802 |
| BF49_2686 | BF49_6537 | Osuccinylbenzoic acidCoA ligase EC 62126. | Porphobilinogen synthase EC 42124; Belongs to the ALAD family. | 0.554 |
| BF49_2686 | BF49_6538 | Osuccinylbenzoic acidCoA ligase EC 62126. | Porphobilinogen synthase EC 42124; Belongs to the ALAD family. | 0.554 |
| BF49_2686 | BF49_6553 | Osuccinylbenzoic acidCoA ligase EC 62126. | Peptide synthetase; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.999 |
| BF49_4033 | BF49_2686 | 5aminolevulinate synthase EC 23137. | Osuccinylbenzoic acidCoA ligase EC 62126. | 0.524 |
| BF49_4033 | BF49_5017 | 5aminolevulinate synthase EC 23137. | Glutamate1semialdehyde21aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.918 |
| BF49_4033 | BF49_5673 | 5aminolevulinate synthase EC 23137. | Glutamate1semialdehyde aminotransferase EC 5438; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.918 |