STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BF49_6263FIG065221 Holliday junction DNA helicase. (444 aa)    
Predicted Functional Partners:
BF49_6262
Serine protease precursor MucDAlgY associated with sigma factor RpoE; Belongs to the peptidase S1C family.
       0.801
BF49_0541
ATPdependent DNA helicase RecQ.
 
 
 0.757
BF49_5936
COG2110 Macro domain possibly ADPribose binding module.
      0.674
nadE
NAD synthetase EC 6315 Glutamine amidotransferase chain of NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
  
 0.654
nadE-2
NAD synthetase EC 6315 Glutamine amidotransferase chain of NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
  
 0.654
BF49_7325
DNA polymerase III beta subunit EC 2777; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...]
    
 
 0.587
BF49_6267
Ribosomal large subunit pseudouridine synthase C EC 42170; Belongs to the pseudouridine synthase RluA family.
 
     0.496
polA
DNA polymerase I EC 2777; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.491
ruvA
Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
 
  
 0.481
BF49_3231
MethylatedDNAproteincysteine methyltransferase EC 21163.
 
   
 0.458
Your Current Organism:
Bradyrhizobium sp.
NCBI taxonomy Id: 376
Other names: B. sp.
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.