SEA07206.1 protein (Desulfuromusa kysingii) - STRING interaction network

Nodes:

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second shell of interactors

Node Content

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

SEA07206.1

Uncharacterized conserved protein. (317 aa)

Predicted Functional Partners:

SDZ89578.1

0.714

SEA47364.1

0.701

SEA12589.1

0.693

SDZ91471.1

0.645

SEA36879.1

0.638

SEA07235.1

0.624

SEA61958.1

0.602

smg

0.595

SDZ95271.1

0.593

SEA25112.1

0.573

Your Current Organism:

Desulfuromusa kysingii

NCBI taxonomy Id: 37625
Other names: D. kysingii, DSM 7343, strain Kysw2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SDZ89578.1	SDZ91471.1	SAMN05660420_00634	SAMN05660420_00711	AsmA-like C-terminal region.	Na+-driven multidrug efflux pump.	0.736
SDZ89578.1	SDZ95271.1	SAMN05660420_00634	SAMN05660420_00856	AsmA-like C-terminal region.	Hypothetical protein.	0.748
SDZ89578.1	SEA07206.1	SAMN05660420_00634	SAMN05660420_01113	AsmA-like C-terminal region.	Uncharacterized conserved protein.	0.714
SDZ89578.1	SEA12589.1	SAMN05660420_00634	SAMN05660420_01296	AsmA-like C-terminal region.	Hypothetical protein.	0.764
SDZ89578.1	SEA25112.1	SAMN05660420_00634	SAMN05660420_01603	AsmA-like C-terminal region.	PTS system, mannose-specific IIC component.	0.623
SDZ89578.1	SEA36879.1	SAMN05660420_00634	SAMN05660420_01896	AsmA-like C-terminal region.	Cytochrome c554 and c-prime.	0.533
SDZ89578.1	SEA47364.1	SAMN05660420_00634	SAMN05660420_02203	AsmA-like C-terminal region.	AsmA protein.	0.775
SDZ89578.1	SEA61958.1	SAMN05660420_00634	SAMN05660420_02639	AsmA-like C-terminal region.	Repeat domain-containing protein.	0.697
SDZ89578.1	smg	SAMN05660420_00634	SAMN05660420_00705	AsmA-like C-terminal region.	Smg protein; Belongs to the Smg family.	0.500
SDZ91471.1	SDZ89578.1	SAMN05660420_00711	SAMN05660420_00634	Na+-driven multidrug efflux pump.	AsmA-like C-terminal region.	0.736
SDZ91471.1	SDZ95271.1	SAMN05660420_00711	SAMN05660420_00856	Na+-driven multidrug efflux pump.	Hypothetical protein.	0.649
SDZ91471.1	SEA07206.1	SAMN05660420_00711	SAMN05660420_01113	Na+-driven multidrug efflux pump.	Uncharacterized conserved protein.	0.645
SDZ91471.1	SEA12589.1	SAMN05660420_00711	SAMN05660420_01296	Na+-driven multidrug efflux pump.	Hypothetical protein.	0.760
SDZ91471.1	SEA25112.1	SAMN05660420_00711	SAMN05660420_01603	Na+-driven multidrug efflux pump.	PTS system, mannose-specific IIC component.	0.669
SDZ91471.1	SEA47364.1	SAMN05660420_00711	SAMN05660420_02203	Na+-driven multidrug efflux pump.	AsmA protein.	0.770
SDZ91471.1	smg	SAMN05660420_00711	SAMN05660420_00705	Na+-driven multidrug efflux pump.	Smg protein; Belongs to the Smg family.	0.780
SDZ95271.1	SDZ89578.1	SAMN05660420_00856	SAMN05660420_00634	Hypothetical protein.	AsmA-like C-terminal region.	0.748
SDZ95271.1	SDZ91471.1	SAMN05660420_00856	SAMN05660420_00711	Hypothetical protein.	Na+-driven multidrug efflux pump.	0.649
SDZ95271.1	SEA07206.1	SAMN05660420_00856	SAMN05660420_01113	Hypothetical protein.	Uncharacterized conserved protein.	0.593
SDZ95271.1	SEA12589.1	SAMN05660420_00856	SAMN05660420_01296	Hypothetical protein.	Hypothetical protein.	0.676

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.926

expected number of edges:

12

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006006

Glucose metabolic process

6 of 12

2.19

3.99

3.96e-09

GO:0006096

Glycolytic process

5 of 8

2.29

3.67

4.16e-08

GO:0005975

Carbohydrate metabolic process

8 of 222

1.05

1.19

2.76e-06

GO:1901575

Organic substance catabolic process

6 of 137

1.14

1.16

7.46e-05

GO:0006094

Gluconeogenesis

2 of 6

2.02

1.13

0.0070

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016620

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

4 of 21

1.78

1.6

0.00040

GO:0050661

NADP binding

3 of 14

1.83

1.25

0.0031

GO:0051287

NAD binding

3 of 23

1.61

0.98

0.0089

GO:0016861

Intramolecular oxidoreductase activity, interconverting aldoses and ketoses

2 of 8

1.89

0.7

0.0483

GO:0003824

Catalytic activity

11 of 1707

0.3

0.23

0.0483

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1047

0.48

0.36

0.0059

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:941

Pentose phosphate pathway, and Glyceraldehyde/Erythrose phosphate dehydrogenase family

10 of 25

2.1

6.46

2.44e-17

CL:943

Glycolysis, and Glyceraldehyde/Erythrose phosphate dehydrogenase family

8 of 13

2.28

6.22

1.78e-14

CL:947

Glyceraldehyde 3-phosphate dehydrogenase, active site, and Glycolysis

5 of 5

2.5

4.32

3.77e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00010

Glycolysis / Gluconeogenesis

9 of 37

1.88

4.81

1.92e-14

map01200

Carbon metabolism

11 of 95

1.56

3.53

1.67e-15

map00030

Pentose phosphate pathway

5 of 24

1.81

2.7

3.99e-07

map01120

Microbial metabolism in diverse environments

11 of 248

1.14

1.7

1.42e-11

map01230

Biosynthesis of amino acids

7 of 123

1.25

1.61

6.54e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

9 of 849

0.52

0.33

0.0339

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

5 of 8

2.29

3.74

2.81e-08

KW-0312

Gluconeogenesis

2 of 4

2.19

1.01

0.0134

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02800

Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain

3 of 3

2.5

1.95

0.00024

PF01081

KDPG and KHG aldolase

2 of 2

2.5

1.02

0.0136

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020831

Glyceraldehyde/Erythrose phosphate dehydrogenase family

3 of 3

2.5

1.73

0.00062

IPR020829

Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain

3 of 3

2.5

1.73

0.00062

IPR020828

Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain

3 of 3

2.5

1.73

0.00062

IPR013785

Aldolase-type TIM barrel

4 of 48

1.42

1.01

0.0046

IPR020830

Glyceraldehyde 3-phosphate dehydrogenase, active site

2 of 2

2.5

1.01

0.0144

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00846

Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain

3 of 3

2.5

2.29

5.17e-05

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