node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDZ99461.1 | SEA00906.1 | SAMN05660420_00999 | SAMN05660420_01050 | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Rhodanese-related sulfurtransferase. | 0.441 |
SDZ99461.1 | SEA35718.1 | SAMN05660420_00999 | SAMN05660420_01856 | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.999 |
SDZ99461.1 | SEA56798.1 | SAMN05660420_00999 | SAMN05660420_02495 | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | SagB-type dehydrogenase domain-containing protein. | 0.796 |
SDZ99461.1 | birA | SAMN05660420_00999 | SAMN05660420_02351 | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.483 |
SDZ99461.1 | cobQ | SAMN05660420_00999 | SAMN05660420_00772 | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | L-threonine O-3-phosphate decarboxylase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.648 |
SDZ99461.1 | cobT | SAMN05660420_00999 | SAMN05660420_00770 | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.525 |
SEA00906.1 | SDZ99461.1 | SAMN05660420_01050 | SAMN05660420_00999 | Rhodanese-related sulfurtransferase. | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.441 |
SEA00906.1 | SEA35718.1 | SAMN05660420_01050 | SAMN05660420_01856 | Rhodanese-related sulfurtransferase. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.554 |
SEA00906.1 | SEA56798.1 | SAMN05660420_01050 | SAMN05660420_02495 | Rhodanese-related sulfurtransferase. | SagB-type dehydrogenase domain-containing protein. | 0.740 |
SEA00906.1 | SEA74634.1 | SAMN05660420_01050 | SAMN05660420_03039 | Rhodanese-related sulfurtransferase. | Polyketide-type polyunsaturated fatty acid synthase PfaA. | 0.549 |
SEA00906.1 | birA | SAMN05660420_01050 | SAMN05660420_02351 | Rhodanese-related sulfurtransferase. | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.406 |
SEA11981.1 | SEA26967.1 | SAMN05660420_01277 | SAMN05660420_01667 | Hypothetical protein. | Ribosome-dependent ATPase. | 0.799 |
SEA11981.1 | SEA56798.1 | SAMN05660420_01277 | SAMN05660420_02495 | Hypothetical protein. | SagB-type dehydrogenase domain-containing protein. | 0.488 |
SEA26967.1 | SEA11981.1 | SAMN05660420_01667 | SAMN05660420_01277 | Ribosome-dependent ATPase. | Hypothetical protein. | 0.799 |
SEA26967.1 | SEA56798.1 | SAMN05660420_01667 | SAMN05660420_02495 | Ribosome-dependent ATPase. | SagB-type dehydrogenase domain-containing protein. | 0.635 |
SEA26967.1 | SEA74634.1 | SAMN05660420_01667 | SAMN05660420_03039 | Ribosome-dependent ATPase. | Polyketide-type polyunsaturated fatty acid synthase PfaA. | 0.502 |
SEA35718.1 | SDZ99461.1 | SAMN05660420_01856 | SAMN05660420_00999 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.999 |
SEA35718.1 | SEA00906.1 | SAMN05660420_01856 | SAMN05660420_01050 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Rhodanese-related sulfurtransferase. | 0.554 |
SEA35718.1 | SEA56798.1 | SAMN05660420_01856 | SAMN05660420_02495 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | SagB-type dehydrogenase domain-containing protein. | 0.841 |
SEA35718.1 | birA | SAMN05660420_01856 | SAMN05660420_02351 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.596 |