ANF58426.1 protein (Halotalea alkalilenta) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

ANF58426.1

Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily. (337 aa)

Predicted Functional Partners:

ANF59683.1

0.975

ANF56343.1

0.971

ANF57851.1

0.966

ANF58152.1

0.957

ANF56232.1

0.954

ANF56518.1

0.952

ANF56160.1

0.947

ANF57964.1

0.933

ANF56323.1

0.930

ANF59551.1

0.927

Your Current Organism:

Halotalea alkalilenta

NCBI taxonomy Id: 376489
Other names: CECT 7134, DSM 17697, H. alkalilenta, Halotalea alkalilenta Ntougias et al. 2007, strain AW-7

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANF56160.1	ANF58426.1	A5892_00690	A5892_13895	D-ala-D-ala transporter subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.947
ANF56232.1	ANF58426.1	A5892_01100	A5892_13895	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.954
ANF56323.1	ANF58426.1	A5892_01635	A5892_13895	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.930
ANF56343.1	ANF58426.1	A5892_01755	A5892_13895	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.971
ANF56518.1	ANF58426.1	A5892_02735	A5892_13895	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.952
ANF57851.1	ANF58426.1	A5892_10565	A5892_13895	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.966
ANF57964.1	ANF58426.1	A5892_11260	A5892_13895	D-ala-D-ala transporter subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.933
ANF58152.1	ANF58426.1	A5892_12305	A5892_13895	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.957
ANF58426.1	ANF56160.1	A5892_13895	A5892_00690	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	D-ala-D-ala transporter subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.947
ANF58426.1	ANF56232.1	A5892_13895	A5892_01100	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.954
ANF58426.1	ANF56323.1	A5892_13895	A5892_01635	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.930
ANF58426.1	ANF56343.1	A5892_13895	A5892_01755	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.971
ANF58426.1	ANF56518.1	A5892_13895	A5892_02735	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.952
ANF58426.1	ANF57851.1	A5892_13895	A5892_10565	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.966
ANF58426.1	ANF57964.1	A5892_13895	A5892_11260	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	D-ala-D-ala transporter subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.933
ANF58426.1	ANF58152.1	A5892_13895	A5892_12305	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.957
ANF58426.1	ANF59551.1	A5892_13895	A5892_07550	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.927
ANF58426.1	ANF59683.1	A5892_13895	A5892_13890	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.975
ANF59551.1	ANF58426.1	A5892_07550	A5892_13895	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.927
ANF59683.1	ANF58426.1	A5892_13890	A5892_13895	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.975

Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

3

PPI enrichment p-value:

0.565

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006383

Transcription by RNA polymerase III

8 of 25

2.29

6.02

7.19e-14

GO:0006384

Transcription initiation from RNA polymerase III promoter

5 of 8

2.59

4.44

2.90e-09

GO:0042791

5S class rRNA transcription by RNA polymerase III

4 of 4

2.79

3.81

8.35e-08

GO:0098781

ncRNA transcription

6 of 45

1.91

3.28

2.10e-08

GO:0006351

Transcription, DNA-templated

10 of 191

1.51

2.91

7.87e-12

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000995

RNA polymerase III general transcription initiation factor activity

2 of 3

2.61

0.96

0.0181

GO:0003677

DNA binding

7 of 530

0.91

0.64

0.0071

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090576

RNA polymerase III transcription regulator complex

6 of 7

2.72

5.9

4.87e-12

GO:0000127

Transcription factor TFIIIC complex

4 of 5

2.69

3.58

1.96e-07

GO:0005666

RNA polymerase III complex

4 of 17

2.16

2.66

4.60e-06

GO:0000126

Transcription factor TFIIIB complex

2 of 2

2.79

1.55

0.0015

GO:0032991

Protein-containing complex

10 of 1845

0.52

0.41

0.0018

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1092

RNA Polymerase III Transcription, and RNA polymerase I complex

11 of 33

2.31

8.95

2.72e-22

CL:1147

5S class rRNA transcription by RNA polymerase III

5 of 5

2.79

5.18

1.71e-10

CL:1094

RNA polymerase III complex, and RNA Polymerase I Transcription Initiation

6 of 26

2.15

4.28

4.71e-10

CL:1097

RNA polymerase III complex

4 of 12

2.31

3.07

9.26e-07

CL:1099

RNA polymerase III complex

3 of 7

2.42

2.29

4.67e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

4 of 39

1.8

1.92

6.39e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-76066

RNA Polymerase III Transcription Initiation From Type 2 Promoter

10 of 26

2.37

8.52

4.52e-20

MAP-76061

RNA Polymerase III Transcription Initiation From Type 1 Promoter

10 of 26

2.37

8.52

4.52e-20

MAP-76046

RNA Polymerase III Transcription Initiation

10 of 26

2.37

8.52

4.52e-20

MAP-74158

RNA Polymerase III Transcription

10 of 26

2.37

8.52

4.52e-20

MAP-74160

Gene expression (Transcription)

10 of 477

1.11

1.48

6.30e-09

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

4 of 77

1.51

1.02

0.0057

GOCC:0005666

RNA polymerase III complex

2 of 6

2.31

0.91

0.0216

GOCC:0032991

Protein-containing complex

10 of 2101

0.47

0.32

0.0216

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0396

Initiation factor

6 of 45

1.91

3.33

1.44e-08

KW-0240

DNA-directed RNA polymerase

2 of 16

1.89

0.81

0.0288

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