A0A0L8FXI9 protein (Octopus bimaculoides) - STRING interaction network

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second shell of interactors

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Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

A0A0L8FXI9

SAE2 domain-containing protein. (413 aa)

Predicted Functional Partners:

A0A0L8FP32

0.996

A0A0L8GKX7

0.994

A0A0L8HAJ9

0.989

A0A0L8GRV3

0.984

A0A0L8HG47

0.973

A0A0L8HBQ1

0.933

A0A0L8FFQ7

0.902

A0A0L8FFY1

0.902

A0A0L8FU32

0.892

A0A0L8H0W6

0.871

Your Current Organism:

Octopus bimaculoides

NCBI taxonomy Id: 37653
Other names: O. bimaculoides

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A0L8FFQ7	A0A0L8FP32	BRCT domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.885
A0A0L8FFQ7	A0A0L8FU32	BRCT domain-containing protein.	Non-specific serine/threonine protein kinase.	0.790
A0A0L8FFQ7	A0A0L8FXI9	BRCT domain-containing protein.	SAE2 domain-containing protein.	0.902
A0A0L8FFQ7	A0A0L8GKX7	BRCT domain-containing protein.	Zinc-hook domain-containing protein.	0.756
A0A0L8FFQ7	A0A0L8GRV3	BRCT domain-containing protein.	FHA domain-containing protein.	0.755
A0A0L8FFQ7	A0A0L8H0W6	BRCT domain-containing protein.	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.	0.859
A0A0L8FFQ7	A0A0L8HBQ1	BRCT domain-containing protein.	Uncharacterized protein.	0.699
A0A0L8FFQ7	A0A0L8HG47	BRCT domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.920
A0A0L8FFY1	A0A0L8FP32	BRCT domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.885
A0A0L8FFY1	A0A0L8FU32	BRCT domain-containing protein.	Non-specific serine/threonine protein kinase.	0.790
A0A0L8FFY1	A0A0L8FXI9	BRCT domain-containing protein.	SAE2 domain-containing protein.	0.902
A0A0L8FFY1	A0A0L8GKX7	BRCT domain-containing protein.	Zinc-hook domain-containing protein.	0.756
A0A0L8FFY1	A0A0L8GRV3	BRCT domain-containing protein.	FHA domain-containing protein.	0.755
A0A0L8FFY1	A0A0L8H0W6	BRCT domain-containing protein.	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.	0.859
A0A0L8FFY1	A0A0L8HBQ1	BRCT domain-containing protein.	Uncharacterized protein.	0.699
A0A0L8FFY1	A0A0L8HG47	BRCT domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.920
A0A0L8FP32	A0A0L8FFQ7	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	BRCT domain-containing protein.	0.885
A0A0L8FP32	A0A0L8FFY1	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	BRCT domain-containing protein.	0.885
A0A0L8FP32	A0A0L8FU32	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Non-specific serine/threonine protein kinase.	0.987
A0A0L8FP32	A0A0L8FXI9	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	SAE2 domain-containing protein.	0.996

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Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.84

expected number of edges:

30

PPI enrichment p-value:

0.636

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006098

Pentose-phosphate shunt

6 of 14

2.53

5.23

4.93e-11

GO:0019253

Reductive pentose-phosphate cycle

4 of 12

2.42

3.15

8.35e-07

GO:0019521

D-gluconate metabolic process

2 of 3

2.72

1.53

0.0016

GO:0019323

Pentose catabolic process

2 of 4

2.6

1.46

0.0021

GO:0019637

Organophosphate metabolic process

7 of 329

1.23

1.45

5.79e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004802

Transketolase activity

4 of 4

2.9

3.8

9.75e-08

GO:0004750

D-ribulose-phosphate 3-epimerase activity

2 of 2

2.9

1.4

0.0029

GO:0004616

Phosphogluconate dehydrogenase (decarboxylating) activity

2 of 2

2.9

1.4

0.0029

GO:0046872

Metal ion binding

7 of 963

0.76

0.53

0.0093

GO:0003824

Catalytic activity

11 of 4103

0.33

0.25

0.0328

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

8 of 826

0.88

0.81

0.00015

GO:0005737

Cytoplasm

10 of 2873

0.44

0.33

0.0105

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:31562384

(2020) Horizontal acquisition of a patchwork Calvin cycle by symbiotic and free-living Campylobacterota (formerly Epsilonproteobacteria).

5 of 29

2.13

3.33

1.11e-07

PMID:34310854

(2021) Metabolic engineering of Escherichia coli for biosynthesis of beta-nicotinamide mononucleotide from nicotinamide.

2 of 10

2.2

0.95

0.0174

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2818

Pentose phosphate pathway, and Glycolysis

11 of 37

2.37

9.43

7.70e-23

CL:2852

Transketolase activity, and Ribulose-phosphate 3-epimerase

7 of 7

2.9

8.13

3.10e-16

CL:2819

Mixed, incl. Glycolysis, and Transketolase activity

8 of 24

2.42

7.22

3.91e-16

CL:2866

Glucose 6-phosphate metabolic process, and ROK family

3 of 13

2.26

2.01

0.00014

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00030

Pentose phosphate pathway

11 of 62

2.15

7.87

9.11e-22

map01200

Carbon metabolism

10 of 277

1.46

2.82

9.64e-13

map01230

Biosynthesis of amino acids

8 of 224

1.45

2.43

1.61e-09

map01110

Biosynthesis of secondary metabolites

10 of 930

0.93

1.06

7.11e-08

map01120

Microbial metabolism in diverse environments

10 of 1111

0.85

0.91

3.27e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005829

Cytosol

7 of 1072

0.71

0.46

0.0175

GOCC:0005737

Cytoplasm

10 of 2237

0.55

0.41

0.0041

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0786

Thiamine pyrophosphate

3 of 26

1.96

1.66

0.00047

KW-0119

Carbohydrate metabolism

3 of 36

1.82

1.48

0.00088

KW-0460

Magnesium

5 of 153

1.41

1.46

0.00012

KW-0170

Cobalt

2 of 13

2.09

1.12

0.0076

KW-0479

Metal-binding

7 of 481

1.06

1.03

0.00012

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02780

Transketolase, C-terminal domain

4 of 7

2.66

3.38

4.54e-07

PF00456

Transketolase, thiamine diphosphate binding domain

3 of 6

2.6

2.27

6.30e-05

PF00834

Ribulose-phosphate 3 epimerase family

2 of 2

2.9

1.4

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033248

Transketolase, C-terminal domain

4 of 7

2.66

3.18

1.16e-06

IPR005475

Transketolase-like, pyrimidine-binding domain

4 of 8

2.6

3.16

1.16e-06

IPR009014

Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II

4 of 13

2.39

2.89

2.77e-06

IPR033247

Transketolase family

3 of 3

2.9

2.58

1.92e-05

IPR005478

Transketolase, bacterial-like

3 of 3

2.9

2.58

1.92e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00861

Transketolase, pyrimidine binding domain

4 of 8

2.6

3.66

1.16e-07

SM01350

6-phosphogluconate dehydrogenase, C-terminal domain

2 of 2

2.9

1.73

0.00074

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