A0A0L8GD18 protein (Octopus bimaculoides) - STRING interaction network

Nodes:

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

A0A0L8GD18

Uncharacterized protein. (567 aa)

Predicted Functional Partners:

A0A0L8FL66

0.677

A0A0L8FRX5

0.677

A0A0L8FW37

0.677

A0A0L8GXL1

0.585

A0A0L8IDB0

0.569

A0A0L8FHS0

0.567

A0A0L8GSR2

0.563

A0A0L8H1Q1

0.557

A0A0L8FMS7

0.550

A0A0L8FMP3

0.548

Your Current Organism:

Octopus bimaculoides

NCBI taxonomy Id: 37653
Other names: O. bimaculoides

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A0L8FHS0	A0A0L8FMS7	Uncharacterized protein.	FCP1 homology domain-containing protein.	0.548
A0A0L8FHS0	A0A0L8GD18	Uncharacterized protein.	Uncharacterized protein.	0.567
A0A0L8FHS0	A0A0L8GSR2	Uncharacterized protein.	Transket_pyr domain-containing protein.	0.563
A0A0L8FHS0	A0A0L8IDB0	Uncharacterized protein.	SH3 domain-containing protein.	0.560
A0A0L8FL66	A0A0L8GD18	Uncharacterized protein.	Uncharacterized protein.	0.677
A0A0L8FMP3	A0A0L8GD18	Uncharacterized protein.	Uncharacterized protein.	0.548
A0A0L8FMS7	A0A0L8FHS0	FCP1 homology domain-containing protein.	Uncharacterized protein.	0.548
A0A0L8FMS7	A0A0L8GD18	FCP1 homology domain-containing protein.	Uncharacterized protein.	0.550
A0A0L8FMS7	A0A0L8GSR2	FCP1 homology domain-containing protein.	Transket_pyr domain-containing protein.	0.482
A0A0L8FMS7	A0A0L8IDB0	FCP1 homology domain-containing protein.	SH3 domain-containing protein.	0.474
A0A0L8FRX5	A0A0L8FW37	Uncharacterized protein.	4Fe-4S ferredoxin-type domain-containing protein.	0.949
A0A0L8FRX5	A0A0L8GD18	Uncharacterized protein.	Uncharacterized protein.	0.677
A0A0L8FW37	A0A0L8FRX5	4Fe-4S ferredoxin-type domain-containing protein.	Uncharacterized protein.	0.949
A0A0L8FW37	A0A0L8GD18	4Fe-4S ferredoxin-type domain-containing protein.	Uncharacterized protein.	0.677
A0A0L8GD18	A0A0L8FHS0	Uncharacterized protein.	Uncharacterized protein.	0.567
A0A0L8GD18	A0A0L8FL66	Uncharacterized protein.	Uncharacterized protein.	0.677
A0A0L8GD18	A0A0L8FMP3	Uncharacterized protein.	Uncharacterized protein.	0.548
A0A0L8GD18	A0A0L8FMS7	Uncharacterized protein.	FCP1 homology domain-containing protein.	0.550
A0A0L8GD18	A0A0L8FRX5	Uncharacterized protein.	Uncharacterized protein.	0.677
A0A0L8GD18	A0A0L8FW37	Uncharacterized protein.	4Fe-4S ferredoxin-type domain-containing protein.	0.677

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016126

Sterol biosynthetic process

11 of 32

2.93

14.09

1.12e-28

GO:0006696

Ergosterol biosynthetic process

8 of 22

2.96

10.08

4.89e-20

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016491

Oxidoreductase activity

8 of 869

1.36

1.9

2.26e-07

GO:0003838

Sterol 24-C-methyltransferase activity

2 of 2

3.4

1.85

0.00047

GO:0016705

Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

4 of 183

1.74

1.55

0.00047

GO:0016709

Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

2 of 11

2.66

1.41

0.0027

GO:0016628

Oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

2 of 16

2.49

1.28

0.0045

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005783

Endoplasmic reticulum

11 of 765

1.55

3.45

6.90e-15

GO:0005811

Lipid droplet

3 of 21

2.55

2.67

9.71e-06

GO:0005789

Endoplasmic reticulum membrane

8 of 644

1.49

2.48

4.03e-09

GO:0030176

Integral component of endoplasmic reticulum membrane

2 of 55

1.96

1.01

0.0116

GO:0016020

Membrane

9 of 3597

0.8

0.74

3.61e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18684

Steroid biosynthesis, and 3-beta-hydroxy-delta5-steroid dehydrogenase activity

11 of 19

3.16

15.74

7.52e-31

CL:18687

Steroid biosynthesis

10 of 12

3.32

15.08

6.12e-29

CL:18691

Fatty acid hydroxylase, and Squalene synthase-like

4 of 5

3.3

5.34

1.93e-10

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00100

Steroid biosynthesis

10 of 27

2.97

13.33

8.15e-27

map01110

Biosynthesis of secondary metabolites

10 of 605

1.62

3.65

2.27e-14

map01100

Metabolic pathways

10 of 2574

0.99

1.19

2.57e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-191273

Cholesterol biosynthesis

8 of 26

2.89

9.55

3.49e-19

MAP-8957322

Metabolism of steroids

8 of 132

2.18

5.84

2.84e-14

MAP-556833

Metabolism of lipids

8 of 479

1.62

3.01

4.55e-10

MAP-1430728

Metabolism

8 of 1637

1.09

1.22

5.36e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098827

Endoplasmic reticulum subcompartment

4 of 58

2.24

2.61

7.42e-06

GOCC:0005789

Endoplasmic reticulum membrane

4 of 480

1.32

0.86

0.0092

GOCC:0012505

Endomembrane system

5 of 1127

1.04

0.71

0.0092

GOCC:0043226

Organelle

9 of 6908

0.51

0.35

0.0185

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0489

Methyltransferase

2 of 50

2.0

1.03

0.0111

KW-0949

S-adenosyl-L-methionine

2 of 57

1.94

1.01

0.0114

KW-1133

Transmembrane helix

7 of 2759

0.8

0.58

0.0055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08498

Sterol methyltransferase C-terminal

2 of 2

3.4

1.68

0.00096

PF01222

Ergosterol biosynthesis ERG4/ERG24 family

2 of 3

3.22

1.67

0.00096

PF04116

Fatty acid hydroxylase

2 of 5

3.0

1.64

0.0011

PF13489

Methyltransferase domain

2 of 30

2.22

0.92

0.0196

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030384

SAM-dependent methyltransferase SMT-type

2 of 2

3.4

1.44

0.0026

IPR018083

Sterol reductase, conserved site

2 of 3

3.22

1.44

0.0026

IPR013705

Sterol methyltransferase C-terminal

2 of 2

3.4

1.44

0.0026

IPR001171

Sterol biosynthesis ERG24/DHCR-like

2 of 3

3.22

1.44

0.0026

IPR006694

Fatty acid hydroxylase

2 of 5

3.0

1.43

0.0026

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