A0A0L8HCS2 protein (Octopus bimaculoides) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A0L8HCS2

Acetyl-coenzyme A synthetase. (685 aa)

Predicted Functional Partners:

A0A0L8GP61

0.983

A0A0L8GQW4

0.958

A0A0L8I1D3

0.958

A0A0L8I634

0.956

A0A0L8GP20

0.955

A0A0L8H9R0

0.955

A0A0L8HC03

0.955

A0A0L8GHP9

0.952

A0A0L8GP63

0.952

A0A0L8HSS0

0.952

Your Current Organism:

Octopus bimaculoides

NCBI taxonomy Id: 37653
Other names: O. bimaculoides

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A0L8GHP9	A0A0L8GP61	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Citrate synthase; Belongs to the citrate synthase family.	0.468
A0A0L8GHP9	A0A0L8GQW4	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.423
A0A0L8GHP9	A0A0L8HC03	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.876
A0A0L8GHP9	A0A0L8HCS2	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Acetyl-coenzyme A synthetase.	0.952
A0A0L8GHP9	A0A0L8I1D3	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.423
A0A0L8GHP9	A0A0L8I634	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.883
A0A0L8GP20	A0A0L8GP61	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Citrate synthase; Belongs to the citrate synthase family.	0.541
A0A0L8GP20	A0A0L8GQW4	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.463
A0A0L8GP20	A0A0L8HC03	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.898
A0A0L8GP20	A0A0L8HCS2	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Acetyl-coenzyme A synthetase.	0.955
A0A0L8GP20	A0A0L8I1D3	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.463
A0A0L8GP20	A0A0L8I634	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.909
A0A0L8GP61	A0A0L8GHP9	Citrate synthase; Belongs to the citrate synthase family.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.468
A0A0L8GP61	A0A0L8GP20	Citrate synthase; Belongs to the citrate synthase family.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.541
A0A0L8GP61	A0A0L8GP63	Citrate synthase; Belongs to the citrate synthase family.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.468
A0A0L8GP61	A0A0L8GQW4	Citrate synthase; Belongs to the citrate synthase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.973
A0A0L8GP61	A0A0L8H9R0	Citrate synthase; Belongs to the citrate synthase family.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.541
A0A0L8GP61	A0A0L8HCS2	Citrate synthase; Belongs to the citrate synthase family.	Acetyl-coenzyme A synthetase.	0.983
A0A0L8GP61	A0A0L8HSS0	Citrate synthase; Belongs to the citrate synthase family.	Uncharacterized protein; Belongs to the aldehyde dehydrogenase family.	0.468
A0A0L8GP61	A0A0L8I1D3	Citrate synthase; Belongs to the citrate synthase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.973

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.887

expected number of edges:

12

PPI enrichment p-value:

3.43e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

5 of 25

1.76

2.12

1.45e-05

GO:0006399

tRNA metabolic process

6 of 62

1.45

1.73

1.45e-05

GO:0034660

ncRNA metabolic process

7 of 88

1.36

1.67

6.24e-06

GO:0009070

Serine family amino acid biosynthetic process

3 of 10

1.94

1.61

0.00059

GO:0006520

Cellular amino acid metabolic process

7 of 141

1.16

1.27

2.03e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

5 of 24

1.78

2.32

4.40e-06

GO:0140101

Catalytic activity, acting on a tRNA

6 of 48

1.56

2.01

4.40e-06

GO:0140098

Catalytic activity, acting on RNA

7 of 92

1.34

1.66

4.40e-06

GO:0062105

RNA 2-O-methyltransferase activity

2 of 4

2.16

1.04

0.0115

GO:0003723

RNA binding

4 of 100

1.06

0.65

0.0178

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

7 of 364

0.75

0.54

0.0054

GO:0005737

Cytoplasm

10 of 938

0.49

0.37

0.0054

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:386

Aminoacyl-tRNA biosynthesis, and GMP biosynthetic process

4 of 24

1.68

1.39

0.0010

CL:388

Aminoacyl-tRNA synthetase

3 of 12

1.86

1.18

0.0046

CL:392

Aminoacyl-tRNA synthetase, class Ia, anticodon-binding, and Histidine phosphatase superfamily

2 of 5

2.06

0.88

0.0222

CL:888

Cysteine metabolic process, and S-adenosylmethionine metabolic process

2 of 6

1.99

0.87

0.0227

CL:156

Translation, and Transcription, DNA-templated

5 of 139

1.02

0.65

0.0145

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00970

Aminoacyl-tRNA biosynthesis

5 of 30

1.68

2.15

6.06e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005829

Cytosol

8 of 443

0.72

0.57

0.0014

GOCC:0005737

Cytoplasm

11 of 752

0.63

0.56

3.48e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

5 of 23

1.8

2.38

3.25e-06

KW-0648

Protein biosynthesis

5 of 47

1.49

1.71

2.76e-05

KW-0963

Cytoplasm

8 of 226

1.01

1.07

1.03e-05

KW-0489

Methyltransferase

3 of 67

1.11

0.57

0.0431

KW-0862

Zinc

3 of 68

1.11

0.56

0.0431

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF09334

tRNA synthetases class I (M)

3 of 5

2.24

1.66

0.00071

PF00588

SpoU rRNA Methylase family

2 of 3

2.29

0.89

0.0227

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009080

Aminoacyl-tRNA synthetase, class Ia, anticodon-binding

3 of 6

2.16

1.35

0.0028

IPR014729

Rossmann-like alpha/beta/alpha sandwich fold

4 of 31

1.57

1.16

0.0028

IPR001537

tRNA/rRNA methyltransferase, SpoU type

2 of 3

2.29

0.76

0.0396

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About