A0A0L8HT59 protein (Octopus bimaculoides) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A0L8HT59

Uncharacterized protein. (142 aa)

Predicted Functional Partners:

A0A0L8GKA6

0.905

A0A0L8HZR8

0.905

A0A0L8H2R4

0.894

A0A0L8G0E7

0.858

A0A0L8FZ76

0.842

A0A0L8H9X6

0.838

A0A0L8FUD9

0.837

A0A0L8I7R0

0.834

A0A0L8GL19

0.830

A0A0L8GGK3

0.822

Your Current Organism:

Octopus bimaculoides

NCBI taxonomy Id: 37653
Other names: O. bimaculoides

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A0L8FUD9	A0A0L8FZ76	Small nuclear ribonucleoprotein Sm D2.	Uncharacterized protein.	0.980
A0A0L8FUD9	A0A0L8G0E7	Small nuclear ribonucleoprotein Sm D2.	WD_REPEATS_REGION domain-containing protein.	0.978
A0A0L8FUD9	A0A0L8GGK3	Small nuclear ribonucleoprotein Sm D2.	U1 small nuclear ribonucleoprotein C; Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA; Belongs to the U1 small nuclear ribonucleoprotein C family.	0.995
A0A0L8FUD9	A0A0L8GKA6	Small nuclear ribonucleoprotein Sm D2.	Uncharacterized protein.	0.991
A0A0L8FUD9	A0A0L8GL19	Small nuclear ribonucleoprotein Sm D2.	Small nuclear ribonucleoprotein G.	0.999
A0A0L8FUD9	A0A0L8H2R4	Small nuclear ribonucleoprotein Sm D2.	Uncharacterized protein.	0.992
A0A0L8FUD9	A0A0L8H9X6	Small nuclear ribonucleoprotein Sm D2.	Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family.	0.912
A0A0L8FUD9	A0A0L8HT59	Small nuclear ribonucleoprotein Sm D2.	Uncharacterized protein.	0.837
A0A0L8FUD9	A0A0L8HZR8	Small nuclear ribonucleoprotein Sm D2.	Uncharacterized protein.	0.994
A0A0L8FUD9	A0A0L8I7R0	Small nuclear ribonucleoprotein Sm D2.	Uncharacterized protein.	0.999
A0A0L8FZ76	A0A0L8FUD9	Uncharacterized protein.	Small nuclear ribonucleoprotein Sm D2.	0.980
A0A0L8FZ76	A0A0L8G0E7	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.911
A0A0L8FZ76	A0A0L8GGK3	Uncharacterized protein.	U1 small nuclear ribonucleoprotein C; Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA; Belongs to the U1 small nuclear ribonucleoprotein C family.	0.785
A0A0L8FZ76	A0A0L8GKA6	Uncharacterized protein.	Uncharacterized protein.	0.995
A0A0L8FZ76	A0A0L8GL19	Uncharacterized protein.	Small nuclear ribonucleoprotein G.	0.978
A0A0L8FZ76	A0A0L8H2R4	Uncharacterized protein.	Uncharacterized protein.	0.993
A0A0L8FZ76	A0A0L8H9X6	Uncharacterized protein.	Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family.	0.953
A0A0L8FZ76	A0A0L8HT59	Uncharacterized protein.	Uncharacterized protein.	0.842
A0A0L8FZ76	A0A0L8HZR8	Uncharacterized protein.	Uncharacterized protein.	0.993
A0A0L8FZ76	A0A0L8I7R0	Uncharacterized protein.	Uncharacterized protein.	0.981

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

32

PPI enrichment p-value:

6.32e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000103

Sulfate assimilation

4 of 8

2.53

2.87

3.84e-06

GO:0006790

Sulfur compound metabolic process

5 of 139

1.39

1.14

0.0016

GO:0019379

Sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)

2 of 3

2.66

0.93

0.0203

GO:0070814

Hydrogen sulfide biosynthetic process

2 of 5

2.44

0.91

0.0213

GO:0042128

Nitrate assimilation

2 of 6

2.36

0.88

0.0243

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0020037

Heme binding

6 of 53

1.89

2.99

1.13e-07

GO:0043546

Molybdopterin cofactor binding

3 of 4

2.71

2.47

2.83e-05

GO:0030151

Molybdenum ion binding

3 of 5

2.61

2.39

3.62e-05

GO:0050464

Nitrate reductase (NADPH) activity

2 of 2

2.83

1.42

0.0027

GO:0004783

Sulfite reductase (NADPH) activity

2 of 2

2.83

1.42

0.0027

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009337

Sulfite reductase complex (NADPH)

2 of 2

2.83

1.13

0.0089

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9918

Mixed, incl. Nitrate metabolic process, and Sulfate assimilation

10 of 26

2.42

8.8

2.34e-20

CL:9920

Nitrate metabolic process, and O2/CO2 exchange in erythrocytes

5 of 10

2.53

4.57

1.30e-09

CL:9947

Sulfate assimilation

4 of 5

2.74

3.9

5.12e-08

CL:9923

Nitrate reductase activity, and Nitrate import

3 of 5

2.61

2.56

1.71e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00920

Sulfur metabolism

6 of 31

2.12

4.18

6.17e-10

map01100

Metabolic pathways

9 of 1782

0.54

0.4

0.0061

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1480926

O2/CO2 exchange in erythrocytes

2 of 6

2.36

0.71

0.0497

MAP-1237044

Erythrocytes take up carbon dioxide and release oxygen

2 of 6

2.36

0.71

0.0497

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0500

Molybdenum

3 of 6

2.53

2.49

2.21e-05

KW-0408

Iron

5 of 60

1.75

2.29

4.18e-06

KW-0349

Heme

3 of 24

1.93

1.63

0.00051

KW-0274

FAD

3 of 36

1.75

1.39

0.0012

KW-0560

Oxidoreductase

4 of 156

1.24

0.99

0.0022

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00175

Oxidoreductase NAD-binding domain

4 of 8

2.53

3.15

1.07e-06

PF03404

Mo-co oxidoreductase dimerisation domain

3 of 3

2.83

2.56

2.04e-05

PF00174

Oxidoreductase molybdopterin binding domain

3 of 3

2.83

2.56

2.04e-05

PF00970

Oxidoreductase FAD-binding domain

3 of 5

2.61

2.45

2.85e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001433

Oxidoreductase FAD/NAD(P)-binding

4 of 8

2.53

2.92

3.08e-06

IPR017938

Riboflavin synthase-like beta-barrel

4 of 13

2.32

2.65

7.38e-06

IPR017927

FAD-binding domain, ferredoxin reductase-type

4 of 15

2.26

2.61

8.00e-06

IPR039261

Ferredoxin-NADP reductase (FNR), nucleotide-binding domain

4 of 17

2.21

2.55

9.25e-06

IPR036374

Oxidoreductase, molybdopterin-binding domain superfamily

3 of 3

2.83

2.53

2.34e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

3 of 21

1.99

1.47

0.0013

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (20%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About