node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aceF | metG | ATP_00154 | ATP_00376 | Branched-chain alpha-keto acid dehydrogenase subunit E2 (lipoate acyltransferase). | Methiony-tRNA synthetase. | 0.499 |
aceF | pepP | ATP_00154 | ATP_00042 | Branched-chain alpha-keto acid dehydrogenase subunit E2 (lipoate acyltransferase). | Xaa-Pro aminopeptidase. | 0.534 |
aceF | qns | ATP_00154 | ATP_00183 | Branched-chain alpha-keto acid dehydrogenase subunit E2 (lipoate acyltransferase). | Glutamine-dependent NAD(+) synthetase. | 0.529 |
efp | metG | ATP_00124 | ATP_00376 | Translation elongation factor P (EF-P); Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. | Methiony-tRNA synthetase. | 0.580 |
efp | pepP | ATP_00124 | ATP_00042 | Translation elongation factor P (EF-P); Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. | Xaa-Pro aminopeptidase. | 0.501 |
efp | polA | ATP_00124 | ATP_00072 | Translation elongation factor P (EF-P); Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. | DNA polymerase I (3'-5' exonuclease and polymerase domain. | 0.476 |
efp | topA | ATP_00124 | ATP_00075 | Translation elongation factor P (EF-P); Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.548 |
ileS | metG | ATP_00252 | ATP_00376 | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | Methiony-tRNA synthetase. | 0.983 |
ileS | pepP | ATP_00252 | ATP_00042 | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | Xaa-Pro aminopeptidase. | 0.548 |
ileS | polA | ATP_00252 | ATP_00072 | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | DNA polymerase I (3'-5' exonuclease and polymerase domain. | 0.596 |
ileS | topA | ATP_00252 | ATP_00075 | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.597 |
ileS | trpS | ATP_00252 | ATP_00092 | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.515 |
mdlA | mdlB | ATP_00110 | ATP_00111 | Multidrug efflux pump, ATP-binding and permease protein. | Multidrug efflux pump, ATP-binding and permease protein. | 0.986 |
mdlA | pepP | ATP_00110 | ATP_00042 | Multidrug efflux pump, ATP-binding and permease protein. | Xaa-Pro aminopeptidase. | 0.490 |
mdlB | mdlA | ATP_00111 | ATP_00110 | Multidrug efflux pump, ATP-binding and permease protein. | Multidrug efflux pump, ATP-binding and permease protein. | 0.986 |
mdlB | pepP | ATP_00111 | ATP_00042 | Multidrug efflux pump, ATP-binding and permease protein. | Xaa-Pro aminopeptidase. | 0.490 |
metG | aceF | ATP_00376 | ATP_00154 | Methiony-tRNA synthetase. | Branched-chain alpha-keto acid dehydrogenase subunit E2 (lipoate acyltransferase). | 0.499 |
metG | efp | ATP_00376 | ATP_00124 | Methiony-tRNA synthetase. | Translation elongation factor P (EF-P); Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. | 0.580 |
metG | ileS | ATP_00376 | ATP_00252 | Methiony-tRNA synthetase. | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | 0.983 |
metG | pepP | ATP_00376 | ATP_00042 | Methiony-tRNA synthetase. | Xaa-Pro aminopeptidase. | 0.532 |