Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
aceFBranched-chain alpha-keto acid dehydrogenase subunit E2 (lipoate acyltransferase). (419 aa)    
Predicted Functional Partners:
lpd
Dihydrolipoamide dehydrogenase.
 
 0.999
acoB
Thiamine pyrophosphate-dependent dehydrogenase, E1 component (beta subunit, PdhB-like).
 
 0.999
acoA
Thiamine pyrophosphate-dependent dehydrogenase, E1 component alpha subunit (pyruvate dehydrogenase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
  
 0.998
lplA
Lipoate-protein ligase A.
  
 0.933
pduL
CoA-phosphotransacetylase, similar to propanediol FT utilization protein PduL.
     
 0.907
acpP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
  
 0.874
lonA
ATP-dependent proteinase La 1 (Lon); ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
  
 
  0.788
groEL
Chaperonin 60kDa, large subunit; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family.
  
 0.708
dnaK
Molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.667
trx
Thioredoxin.
  
 
 0.654
Your Current Organism:
Phytoplasma mali
NCBI taxonomy Id: 37692
Other names: Apple proliferation mycoplasma-like organism, Apple proliferation phytoplasma, C. Phytoplasma mali, Candidatus Phytoplasma mali
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