| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| glyA | groEL | ATP_00142 | ATP_00185 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Chaperonin 60kDa, large subunit; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | 0.588 |
| glyA | polA | ATP_00142 | ATP_00072 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | DNA polymerase I (3'-5' exonuclease and polymerase domain. | 0.588 |
| glyA | prfA | ATP_00142 | ATP_00175 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Peptide chain release factor 1 (RF-1). | 0.521 |
| glyA | qns | ATP_00142 | ATP_00183 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glutamine-dependent NAD(+) synthetase. | 0.632 |
| groEL | glyA | ATP_00185 | ATP_00142 | Chaperonin 60kDa, large subunit; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.588 |
| groEL | polA | ATP_00185 | ATP_00072 | Chaperonin 60kDa, large subunit; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | DNA polymerase I (3'-5' exonuclease and polymerase domain. | 0.688 |
| groEL | qns | ATP_00185 | ATP_00183 | Chaperonin 60kDa, large subunit; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | Glutamine-dependent NAD(+) synthetase. | 0.693 |
| groEL | rpoD | ATP_00185 | ATP_00306 | Chaperonin 60kDa, large subunit; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | DNA-dependent RNA polymerase sigma subunits; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.743 |
| groEL | thiJ | ATP_00185 | ATP_00237 | Chaperonin 60kDa, large subunit; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | 4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme. | 0.485 |
| groEL | trmU | ATP_00185 | ATP_00182 | Chaperonin 60kDa, large subunit; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | tRNA (5-methylaminomethyl-2-thioruidylate) methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | 0.469 |
| mutT | polA | ATP_00108 | ATP_00072 | NTP pyrophosphohydrolases including oxidative damage repair enzymes; Belongs to the Nudix hydrolase family. | DNA polymerase I (3'-5' exonuclease and polymerase domain. | 0.648 |
| mutT | qns | ATP_00108 | ATP_00183 | NTP pyrophosphohydrolases including oxidative damage repair enzymes; Belongs to the Nudix hydrolase family. | Glutamine-dependent NAD(+) synthetase. | 0.631 |
| pepP | polA | ATP_00042 | ATP_00072 | Xaa-Pro aminopeptidase. | DNA polymerase I (3'-5' exonuclease and polymerase domain. | 0.573 |
| pepP | qns | ATP_00042 | ATP_00183 | Xaa-Pro aminopeptidase. | Glutamine-dependent NAD(+) synthetase. | 0.589 |
| polA | glyA | ATP_00072 | ATP_00142 | DNA polymerase I (3'-5' exonuclease and polymerase domain. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.588 |
| polA | groEL | ATP_00072 | ATP_00185 | DNA polymerase I (3'-5' exonuclease and polymerase domain. | Chaperonin 60kDa, large subunit; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | 0.688 |
| polA | mutT | ATP_00072 | ATP_00108 | DNA polymerase I (3'-5' exonuclease and polymerase domain. | NTP pyrophosphohydrolases including oxidative damage repair enzymes; Belongs to the Nudix hydrolase family. | 0.648 |
| polA | pepP | ATP_00072 | ATP_00042 | DNA polymerase I (3'-5' exonuclease and polymerase domain. | Xaa-Pro aminopeptidase. | 0.573 |
| polA | prfA | ATP_00072 | ATP_00175 | DNA polymerase I (3'-5' exonuclease and polymerase domain. | Peptide chain release factor 1 (RF-1). | 0.517 |
| polA | qns | ATP_00072 | ATP_00183 | DNA polymerase I (3'-5' exonuclease and polymerase domain. | Glutamine-dependent NAD(+) synthetase. | 0.585 |