Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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[Homology]
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tmk-2Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (205 aa)    
Predicted Functional Partners:
dut
DUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
  
 
 0.939
nrdA
Ribonucleotide reductase, alpha subunit (Coenzyme B12-dependent; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
 
 0.936
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.936
tdk
Thymidine kinase.
  
 
 0.934
nrdF
Ribonucleoside-diphosphate reductase, beta chain.
  
 
 0.931
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
  
 
0.911
ATP_00402
Conserved hypothetical protein, phage-related; Similar to ATP_00093.
       0.773
dnaG1
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
  
  
 0.672
ATP_00400
Hypothetical protein.
       0.670
ATP_00401
Hypothetical protein.
       0.670
Your Current Organism:
Phytoplasma mali
NCBI taxonomy Id: 37692
Other names: Apple proliferation mycoplasma-like organism, Apple proliferation phytoplasma, C. Phytoplasma mali, Candidatus Phytoplasma mali
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