node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IW18_10670 | IW18_18555 | IW18_10670 | IW18_18555 | 1-pyrroline-5-carboxylate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.942 |
IW18_10670 | IW18_19040 | IW18_10670 | IW18_19040 | 1-pyrroline-5-carboxylate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. | Aspartate aminotransferase; Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.920 |
IW18_10670 | gltA | IW18_10670 | IW18_03965 | 1-pyrroline-5-carboxylate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. | Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. | 0.630 |
IW18_10670 | mdh | IW18_10670 | IW18_19080 | 1-pyrroline-5-carboxylate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.405 |
IW18_13680 | IW18_19040 | IW18_13680 | IW18_19040 | Prephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aspartate aminotransferase; Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.925 |
IW18_13780 | IW18_15140 | IW18_13780 | IW18_15140 | Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. | Argininosuccinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.921 |
IW18_13780 | IW18_18555 | IW18_13780 | IW18_18555 | Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.434 |
IW18_13780 | IW18_19040 | IW18_13780 | IW18_19040 | Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. | Aspartate aminotransferase; Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.934 |
IW18_14210 | IW18_18555 | IW18_14210 | IW18_18555 | Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.917 |
IW18_14210 | IW18_19040 | IW18_14210 | IW18_19040 | Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aspartate aminotransferase; Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.926 |
IW18_14210 | gltA | IW18_14210 | IW18_03965 | Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. | 0.902 |
IW18_14210 | mdh | IW18_14210 | IW18_19080 | Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.912 |
IW18_14990 | IW18_19040 | IW18_14990 | IW18_19040 | Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Aspartate aminotransferase; Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.936 |
IW18_15140 | IW18_13780 | IW18_15140 | IW18_13780 | Argininosuccinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. | 0.921 |
IW18_15140 | IW18_18555 | IW18_15140 | IW18_18555 | Argininosuccinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.904 |
IW18_15140 | IW18_19040 | IW18_15140 | IW18_19040 | Argininosuccinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aspartate aminotransferase; Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.924 |
IW18_17505 | IW18_19040 | IW18_17505 | IW18_19040 | Aminoacyl-histidine dipeptidase; Catalyzes the hydrolysis of Xaa-His dipeptides; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aspartate aminotransferase; Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.929 |
IW18_18555 | IW18_10670 | IW18_18555 | IW18_10670 | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 1-pyrroline-5-carboxylate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. | 0.942 |
IW18_18555 | IW18_13780 | IW18_18555 | IW18_13780 | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. | 0.434 |
IW18_18555 | IW18_14210 | IW18_18555 | IW18_14210 | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.917 |