STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucCsuccinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (381 aa)    
Predicted Functional Partners:
sucD
succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.999
sdhA
Succinate dehydrogenase flavoprotein subunit.
 
 0.987
sdhB
Succinate dehydrogenase iron-sulfur subunit.
  
 0.986
sucB
Dihydrolipoamide acyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
 0.985
GAU_1993
Dihydrolipoamide acyltransferase.
 
 0.984
gltA
Citrate synthase; Belongs to the citrate synthase family.
  
 
 0.981
sucA
2-oxoglutarate dehydrogenase E1 component; Protein synonym: alpha-ketoglutarate dehydrogenase.
 0.969
pdhC
Pyruvate dehydrogenase E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.968
GAU_2381
Putative 2-oxoglutarate ferredoxin-oxidoreductase alpha subunit.
  
 
 0.956
GAU_2382
Putative 2-oxoglutarate ferredoxin-oxidoreductase beta subunit.
  
 
 0.932
Your Current Organism:
Gemmatimonas aurantiaca
NCBI taxonomy Id: 379066
Other names: G. aurantiaca T-27, Gemmatimonas aurantiaca DSM 14586, Gemmatimonas aurantiaca JCM 11422, Gemmatimonas aurantiaca NBRC 100505, Gemmatimonas aurantiaca T-27, Gemmatimonas aurantiaca str. T-27, Gemmatimonas aurantiaca strain T-27
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