node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | SA2016_1703 | SA2016_1700 | Phosphoribosyl isomerase; Pfam:pfam00977 Histidine biosynthesis protein. | Pfam:pfam00475 Imidazoleglycerol-phosphate dehydratase. | 0.998 |
hisA | hisC | SA2016_1703 | SA2016_1699 | Phosphoribosyl isomerase; Pfam:pfam00977 Histidine biosynthesis protein. | Pfam:pfam00155 Aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.988 |
hisA | hisD | SA2016_1703 | SA2016_1826 | Phosphoribosyl isomerase; Pfam:pfam00977 Histidine biosynthesis protein. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.995 |
hisA | hisE | SA2016_1703 | SA2016_1916 | Phosphoribosyl isomerase; Pfam:pfam00977 Histidine biosynthesis protein. | Pfam:pfam01503 Phosphoribosyl-ATP pyrophosphohydrolase. | 0.983 |
hisA | hisF | SA2016_1703 | SA2016_1918 | Phosphoribosyl isomerase; Pfam:pfam00977 Histidine biosynthesis protein. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | SA2016_1703 | SA2016_1917 | Phosphoribosyl isomerase; Pfam:pfam00977 Histidine biosynthesis protein. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.993 |
hisA | hisH | SA2016_1703 | SA2016_1701 | Phosphoribosyl isomerase; Pfam:pfam00977 Histidine biosynthesis protein. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | SA2016_1703 | SA2016_1921 | Phosphoribosyl isomerase; Pfam:pfam00977 Histidine biosynthesis protein. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | pat | SA2016_1703 | SA2016_3719 | Phosphoribosyl isomerase; Pfam:pfam00977 Histidine biosynthesis protein. | Aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.861 |
hisA | purH | SA2016_1703 | SA2016_1351 | Phosphoribosyl isomerase; Pfam:pfam00977 Histidine biosynthesis protein. | Bifunctional purine biosynthesis protein PurH; Pfam:pfam01808 AICARFT/IMPCHase bienzyme. | 0.549 |
hisB | hisA | SA2016_1700 | SA2016_1703 | Pfam:pfam00475 Imidazoleglycerol-phosphate dehydratase. | Phosphoribosyl isomerase; Pfam:pfam00977 Histidine biosynthesis protein. | 0.998 |
hisB | hisC | SA2016_1700 | SA2016_1699 | Pfam:pfam00475 Imidazoleglycerol-phosphate dehydratase. | Pfam:pfam00155 Aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | SA2016_1700 | SA2016_1826 | Pfam:pfam00475 Imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | SA2016_1700 | SA2016_1916 | Pfam:pfam00475 Imidazoleglycerol-phosphate dehydratase. | Pfam:pfam01503 Phosphoribosyl-ATP pyrophosphohydrolase. | 0.984 |
hisB | hisF | SA2016_1700 | SA2016_1918 | Pfam:pfam00475 Imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | SA2016_1700 | SA2016_1917 | Pfam:pfam00475 Imidazoleglycerol-phosphate dehydratase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.994 |
hisB | hisH | SA2016_1700 | SA2016_1701 | Pfam:pfam00475 Imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI | SA2016_1700 | SA2016_1921 | Pfam:pfam00475 Imidazoleglycerol-phosphate dehydratase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.997 |
hisB | pat | SA2016_1700 | SA2016_3719 | Pfam:pfam00475 Imidazoleglycerol-phosphate dehydratase. | Aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.998 |
hisC | hisA | SA2016_1699 | SA2016_1703 | Pfam:pfam00155 Aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Phosphoribosyl isomerase; Pfam:pfam00977 Histidine biosynthesis protein. | 0.988 |