Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AMM33768.1Cystathionine beta-synthase; Pfam:pfam00291 Pyridoxal-phosphate dependent enzyme. (464 aa)    
Predicted Functional Partners:
AMM33767.1
Cystathionine gamma-synthase; Pfam:pfam01053 Cys/Met metabolizm PLP-dependent enzyme.
 0.998
AMM31460.1
Cystathionine gamma-synthase; Pfam:pfam01053 Cys/Met metabolizm PLP-dependent enzyme.
 0.990
AMM34065.1
O-succinylhomoserine sulfhydrylase; Pfam:pfam01053 Cys/Met metabolizm PLP-dependent enzyme.
 0.988
AMM33036.1
Serine acetyltransferase; Pfam:pfam00132 Bacterial transferase hexapeptide (six repeats).
 
 0.975
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 0.946
AMM31189.1
O-acetylhomoserine aminocarboxypropyltransferase; Pfam:pfam01053 Cys/Met metabolizm PLP-dependent enzyme.
 
 
 0.945
AMM32257.1
O-acetylhomoserine (Thiol)-lyase; Pfam:pfam01053 Cys/Met metabolizm PLP-dependent enzyme.
 
 
 0.944
AMM32093.1
Threonine dehydratase; Pfam:pfam00291 Pyridoxal-phosphate dependent enzyme.
 
 
 0.935
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.931
glyA-2
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.931
Your Current Organism:
Sinomonas atrocyanea
NCBI taxonomy Id: 37927
Other names: ATCC 13752, Arthrobacter atricyaneus, Arthrobacter atrocyaneus, CIP 102365, DSM 20127, KCTC 3377, LMG 3814, LMG:3814, NBRC 12956, S. atrocyanea
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