STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDQ56071.1Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (549 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.974
SDQ33466.1
L-threonine ammonia-lyase.
 
 0.939
SDQ31523.1
Regulator of RNase E activity RraA.
    
  0.900
SDR07229.1
Acetolactate synthase, small subunit.
 
 0.891
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 
 0.880
SDR14112.1
Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family.
  
  
0.852
SDQ65196.1
Malate dehydrogenase (oxaloacetate-decarboxylating).
  
 
 0.830
SDQ72928.1
Malate dehydrogenase (oxaloacetate-decarboxylating).
  
 
 0.830
SDQ37506.1
Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family.
  
  
0.827
SDQ72135.1
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 0.824
Your Current Organism:
Arthrobacter crystallopoietes
NCBI taxonomy Id: 37928
Other names: A. crystallopoietes, ATCC 15481, CIP 102717, DSM 20117, IFO 14235, JCM 2522, LMG 3819, LMG:3819, NBRC 14235
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.