node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFN15028.1 | SFN20102.1 | SAMN04487961_2231 | SAMN04487961_2453 | Pyruvate-ferredoxin/flavodoxin oxidoreductase. | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 0.950 |
SFN15028.1 | SFN28994.1 | SAMN04487961_2231 | SAMN04487961_2723 | Pyruvate-ferredoxin/flavodoxin oxidoreductase. | Acetolactate synthase, large subunit. | 0.950 |
SFN15028.1 | SFN32151.1 | SAMN04487961_2231 | SAMN04487961_2758 | Pyruvate-ferredoxin/flavodoxin oxidoreductase. | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 0.972 |
SFN15028.1 | SFN45537.1 | SAMN04487961_2231 | SAMN04487961_3148 | Pyruvate-ferredoxin/flavodoxin oxidoreductase. | Acetolactate synthase, large subunit. | 0.950 |
SFN15028.1 | SFN45563.1 | SAMN04487961_2231 | SAMN04487961_3149 | Pyruvate-ferredoxin/flavodoxin oxidoreductase. | Acetolactate synthase, small subunit. | 0.977 |
SFN15028.1 | ilvA | SAMN04487961_2231 | SAMN04487961_2404 | Pyruvate-ferredoxin/flavodoxin oxidoreductase. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.970 |
SFN15028.1 | ilvC | SAMN04487961_2231 | SAMN04487961_3150 | Pyruvate-ferredoxin/flavodoxin oxidoreductase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.595 |
SFN15028.1 | leuA-2 | SAMN04487961_2231 | SAMN04487961_2990 | Pyruvate-ferredoxin/flavodoxin oxidoreductase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.942 |
SFN15028.1 | leuB | SAMN04487961_2231 | SAMN04487961_0861 | Pyruvate-ferredoxin/flavodoxin oxidoreductase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.972 |
SFN20102.1 | SFN15028.1 | SAMN04487961_2453 | SAMN04487961_2231 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Pyruvate-ferredoxin/flavodoxin oxidoreductase. | 0.950 |
SFN20102.1 | SFN28994.1 | SAMN04487961_2453 | SAMN04487961_2723 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, large subunit. | 0.953 |
SFN20102.1 | SFN29013.1 | SAMN04487961_2453 | SAMN04487961_2724 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit. | 0.953 |
SFN20102.1 | SFN32151.1 | SAMN04487961_2453 | SAMN04487961_2758 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 0.970 |
SFN20102.1 | SFN45537.1 | SAMN04487961_2453 | SAMN04487961_3148 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, large subunit. | 0.955 |
SFN20102.1 | SFN45563.1 | SAMN04487961_2453 | SAMN04487961_3149 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit. | 0.998 |
SFN20102.1 | ilvA | SAMN04487961_2453 | SAMN04487961_2404 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.967 |
SFN20102.1 | ilvC | SAMN04487961_2453 | SAMN04487961_3150 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.982 |
SFN20102.1 | leuA-2 | SAMN04487961_2453 | SAMN04487961_2990 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.912 |
SFN20102.1 | leuB | SAMN04487961_2453 | SAMN04487961_0861 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.969 |
SFN28994.1 | SFN15028.1 | SAMN04487961_2723 | SAMN04487961_2231 | Acetolactate synthase, large subunit. | Pyruvate-ferredoxin/flavodoxin oxidoreductase. | 0.950 |