node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACD | DKC1 | ENSPCOP00000030285 | ENSPCOP00000028469 | ACD shelterin complex subunit and telomerase recruitment factor. | Dyskerin pseudouridine synthase 1. | 0.808 |
ACD | ENSPCOP00000002776 | ENSPCOP00000030285 | ENSPCOP00000002776 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.963 |
ACD | ENSPCOP00000025432 | ENSPCOP00000030285 | ENSPCOP00000025432 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.963 |
ACD | POT1 | ENSPCOP00000030285 | ENSPCOP00000004523 | ACD shelterin complex subunit and telomerase recruitment factor. | Protection of telomeres 1. | 0.998 |
ACD | RPA1 | ENSPCOP00000030285 | ENSPCOP00000000581 | ACD shelterin complex subunit and telomerase recruitment factor. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.672 |
ACD | TRUB1 | ENSPCOP00000030285 | ENSPCOP00000024330 | ACD shelterin complex subunit and telomerase recruitment factor. | TruB pseudouridine synthase family member 1. | 0.638 |
CTNNB1 | ENSPCOP00000002776 | ENSPCOP00000022753 | ENSPCOP00000002776 | Catenin beta 1. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.896 |
CTNNB1 | ENSPCOP00000025432 | ENSPCOP00000022753 | ENSPCOP00000025432 | Catenin beta 1. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.896 |
DKC1 | ACD | ENSPCOP00000028469 | ENSPCOP00000030285 | Dyskerin pseudouridine synthase 1. | ACD shelterin complex subunit and telomerase recruitment factor. | 0.808 |
DKC1 | ENSPCOP00000002776 | ENSPCOP00000028469 | ENSPCOP00000002776 | Dyskerin pseudouridine synthase 1. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.910 |
DKC1 | ENSPCOP00000025432 | ENSPCOP00000028469 | ENSPCOP00000025432 | Dyskerin pseudouridine synthase 1. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.910 |
DKC1 | POT1 | ENSPCOP00000028469 | ENSPCOP00000004523 | Dyskerin pseudouridine synthase 1. | Protection of telomeres 1. | 0.769 |
DKC1 | TRUB1 | ENSPCOP00000028469 | ENSPCOP00000024330 | Dyskerin pseudouridine synthase 1. | TruB pseudouridine synthase family member 1. | 0.522 |
ENSPCOP00000002776 | ACD | ENSPCOP00000002776 | ENSPCOP00000030285 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | ACD shelterin complex subunit and telomerase recruitment factor. | 0.963 |
ENSPCOP00000002776 | CTNNB1 | ENSPCOP00000002776 | ENSPCOP00000022753 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Catenin beta 1. | 0.896 |
ENSPCOP00000002776 | DKC1 | ENSPCOP00000002776 | ENSPCOP00000028469 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Dyskerin pseudouridine synthase 1. | 0.910 |
ENSPCOP00000002776 | ENSPCOP00000025432 | ENSPCOP00000002776 | ENSPCOP00000025432 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.942 |
ENSPCOP00000002776 | KPNA1 | ENSPCOP00000002776 | ENSPCOP00000001446 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Importin subunit alpha; Functions in nuclear protein import. | 0.878 |
ENSPCOP00000002776 | MEIOB | ENSPCOP00000002776 | ENSPCOP00000000779 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Meiosis specific with OB-fold. | 0.869 |
ENSPCOP00000002776 | POT1 | ENSPCOP00000002776 | ENSPCOP00000004523 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Protection of telomeres 1. | 0.978 |