node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDT1 | MCM2 | ENSPCOP00000015353 | ENSPCOP00000011847 | Chromatin licensing and DNA replication factor 1. | DNA helicase; Belongs to the MCM family. | 0.999 |
CDT1 | MCM3 | ENSPCOP00000015353 | ENSPCOP00000006813 | Chromatin licensing and DNA replication factor 1. | DNA helicase; Belongs to the MCM family. | 0.999 |
CDT1 | MCM4 | ENSPCOP00000015353 | ENSPCOP00000006806 | Chromatin licensing and DNA replication factor 1. | DNA helicase; Belongs to the MCM family. | 0.999 |
CDT1 | MCM5 | ENSPCOP00000015353 | ENSPCOP00000006599 | Chromatin licensing and DNA replication factor 1. | DNA helicase; Belongs to the MCM family. | 0.999 |
CDT1 | MCM6 | ENSPCOP00000015353 | ENSPCOP00000015530 | Chromatin licensing and DNA replication factor 1. | DNA helicase; Belongs to the MCM family. | 0.999 |
CDT1 | MCM7 | ENSPCOP00000015353 | ENSPCOP00000006338 | Chromatin licensing and DNA replication factor 1. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
CDT1 | ORC1 | ENSPCOP00000015353 | ENSPCOP00000024514 | Chromatin licensing and DNA replication factor 1. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.999 |
CDT1 | ORC2 | ENSPCOP00000015353 | ENSPCOP00000019654 | Chromatin licensing and DNA replication factor 1. | Origin recognition complex subunit 2. | 0.999 |
CDT1 | ORC3 | ENSPCOP00000015353 | ENSPCOP00000022584 | Chromatin licensing and DNA replication factor 1. | Origin recognition complex subunit 3. | 0.999 |
CDT1 | ORC4 | ENSPCOP00000015353 | ENSPCOP00000001597 | Chromatin licensing and DNA replication factor 1. | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. | 0.999 |
MCM2 | CDT1 | ENSPCOP00000011847 | ENSPCOP00000015353 | DNA helicase; Belongs to the MCM family. | Chromatin licensing and DNA replication factor 1. | 0.999 |
MCM2 | MCM3 | ENSPCOP00000011847 | ENSPCOP00000006813 | DNA helicase; Belongs to the MCM family. | DNA helicase; Belongs to the MCM family. | 0.999 |
MCM2 | MCM4 | ENSPCOP00000011847 | ENSPCOP00000006806 | DNA helicase; Belongs to the MCM family. | DNA helicase; Belongs to the MCM family. | 0.999 |
MCM2 | MCM5 | ENSPCOP00000011847 | ENSPCOP00000006599 | DNA helicase; Belongs to the MCM family. | DNA helicase; Belongs to the MCM family. | 0.999 |
MCM2 | MCM6 | ENSPCOP00000011847 | ENSPCOP00000015530 | DNA helicase; Belongs to the MCM family. | DNA helicase; Belongs to the MCM family. | 0.999 |
MCM2 | MCM7 | ENSPCOP00000011847 | ENSPCOP00000006338 | DNA helicase; Belongs to the MCM family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
MCM2 | ORC1 | ENSPCOP00000011847 | ENSPCOP00000024514 | DNA helicase; Belongs to the MCM family. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.999 |
MCM2 | ORC2 | ENSPCOP00000011847 | ENSPCOP00000019654 | DNA helicase; Belongs to the MCM family. | Origin recognition complex subunit 2. | 0.999 |
MCM2 | ORC3 | ENSPCOP00000011847 | ENSPCOP00000022584 | DNA helicase; Belongs to the MCM family. | Origin recognition complex subunit 3. | 0.998 |
MCM2 | ORC4 | ENSPCOP00000011847 | ENSPCOP00000001597 | DNA helicase; Belongs to the MCM family. | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. | 0.999 |