node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDIPT | CEPT1 | ENSPCOP00000000599 | ENSPCOP00000031464 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase. | Choline/ethanolamine phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.491 |
CDIPT | CRLS1 | ENSPCOP00000000599 | ENSPCOP00000016587 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase. | Cardiolipin synthase 1. | 0.920 |
CDIPT | KMO | ENSPCOP00000000599 | ENSPCOP00000012522 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 0.880 |
CDIPT | PEMT | ENSPCOP00000000599 | ENSPCOP00000027569 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase. | Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. | 0.552 |
CDIPT | PGS1 | ENSPCOP00000000599 | ENSPCOP00000016071 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family. | 0.942 |
CDIPT | PISD | ENSPCOP00000000599 | ENSPCOP00000026194 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase. | Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. | 0.967 |
CDIPT | PLD1 | ENSPCOP00000000599 | ENSPCOP00000000285 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase. | Phospholipase. | 0.674 |
CDIPT | PLD2 | ENSPCOP00000000599 | ENSPCOP00000001346 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase. | Phospholipase. | 0.674 |
CEPT1 | CDIPT | ENSPCOP00000031464 | ENSPCOP00000000599 | Choline/ethanolamine phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | CDP-diacylglycerol--inositol 3-phosphatidyltransferase. | 0.491 |
CEPT1 | KMO | ENSPCOP00000031464 | ENSPCOP00000012522 | Choline/ethanolamine phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 0.743 |
CEPT1 | PEMT | ENSPCOP00000031464 | ENSPCOP00000027569 | Choline/ethanolamine phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. | 0.935 |
CEPT1 | PGS1 | ENSPCOP00000031464 | ENSPCOP00000016071 | Choline/ethanolamine phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family. | 0.681 |
CEPT1 | PISD | ENSPCOP00000031464 | ENSPCOP00000026194 | Choline/ethanolamine phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. | 0.918 |
CEPT1 | PLD1 | ENSPCOP00000031464 | ENSPCOP00000000285 | Choline/ethanolamine phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phospholipase. | 0.880 |
CEPT1 | PLD2 | ENSPCOP00000031464 | ENSPCOP00000001346 | Choline/ethanolamine phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phospholipase. | 0.880 |
CEPT1 | PTDSS1 | ENSPCOP00000031464 | ENSPCOP00000004368 | Choline/ethanolamine phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidylserine synthase 1. | 0.876 |
CEPT1 | PTDSS2 | ENSPCOP00000031464 | ENSPCOP00000010670 | Choline/ethanolamine phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidylserine synthase 2. | 0.905 |
CRLS1 | CDIPT | ENSPCOP00000016587 | ENSPCOP00000000599 | Cardiolipin synthase 1. | CDP-diacylglycerol--inositol 3-phosphatidyltransferase. | 0.920 |
CRLS1 | KMO | ENSPCOP00000016587 | ENSPCOP00000012522 | Cardiolipin synthase 1. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 0.863 |
CRLS1 | PGS1 | ENSPCOP00000016587 | ENSPCOP00000016071 | Cardiolipin synthase 1. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family. | 0.941 |