STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metFUnannotated protein; Belongs to the methylenetetrahydrofolate reductase family. (296 aa)    
Predicted Functional Partners:
metH
Unannotated protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
 
 
 0.997
metL
Unannotated protein; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.978
metE
Unannotated protein; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
 
 0.978
thrA
Unannotated protein; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.963
metK
Unannotated protein; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.931
GM31_06245
Unannotated protein.
  
 0.921
glyA
Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.912
metAS
Unannotated protein; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family.
  
  
 0.910
GM31_02250
Unannotated protein.
    
 0.877
GM31_00505
Unannotated protein.
    
 0.875
Your Current Organism:
Trabulsiella odontotermitis
NCBI taxonomy Id: 379893
Other names: BCRC 17577, Enterobacteriaceae bacterium Eant 3-3, Enterobacteriaceae bacterium Eant 3-9, LMG 23580, LMG:23580, T. odontotermitis, Trabulsiella odontotermitis Chou et al. 2007, strain Eant 3-9
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