Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
E0Z10_g8766Glutaredoxin; Belongs to the glutaredoxin family. Monothiol subfamily. (156 aa)    
Predicted Functional Partners:
E0Z10_g921
Uncharacterized protein; Belongs to the BolA/IbaG family.
  
 
 0.950
DRE2
Fe-S cluster assembly protein DRE2; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by [...]
   
 
 0.942
E0Z10_g10445
PUM-HD domain-containing protein.
    
 
 0.919
E0Z10_g2446
Uncharacterized protein; Belongs to the BolA/IbaG family.
  
 
 0.887
E0Z10_g1656
Fe-S_biosyn domain-containing protein.
  
 0.882
E0Z10_g5201
Uncharacterized protein; Belongs to the BolA/IbaG family.
  
 
 0.863
TAH18
NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of DRE2. Positively controls H(2)O(2)-induced cell death; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
    
 
 0.854
E0Z10_g656
Uncharacterized protein.
  
 0.854
E0Z10_g4483
Glutaredoxin domain-containing protein.
  
 
 0.817
E0Z10_g3328
Nfu_N domain-containing protein.
   
 
 0.807
Your Current Organism:
Xylaria hypoxylon
NCBI taxonomy Id: 37992
Other names: X. hypoxylon
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