| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| E0Z10_g1045 | E0Z10_g10644 | A0A4Z0YUH6 | A0A4Z0Y319 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 3'-5' exonuclease domain-containing protein. | 0.991 |
| E0Z10_g1045 | E0Z10_g2443 | A0A4Z0YUH6 | A0A4Z0YR18 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | DUF1767 domain-containing protein. | 0.994 |
| E0Z10_g1045 | E0Z10_g3076 | A0A4Z0YUH6 | A0A4Z0Z2U0 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | HRDC domain-containing protein. | 0.991 |
| E0Z10_g1045 | E0Z10_g3911 | A0A4Z0YUH6 | A0A4Z0YMB2 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | ERCC4 domain-containing protein. | 0.991 |
| E0Z10_g1045 | E0Z10_g4542 | A0A4Z0YUH6 | A0A4Z0YK28 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | 0.991 |
| E0Z10_g1045 | E0Z10_g4703 | A0A4Z0YUH6 | A0A4Z0Z3E5 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Uncharacterized protein. | 0.965 |
| E0Z10_g1045 | E0Z10_g6291 | A0A4Z0YUH6 | A0A4Z0YR54 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Uncharacterized protein. | 0.993 |
| E0Z10_g1045 | E0Z10_g7289 | A0A4Z0YUH6 | A0A4Z0YSP7 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | ERCC4 domain-containing protein. | 0.955 |
| E0Z10_g1045 | E0Z10_g9846 | A0A4Z0YUH6 | A0A4Z0YMM3 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | 0.989 |
| E0Z10_g1045 | SLX1 | A0A4Z0YUH6 | A0A4Z0Z696 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. | 0.953 |
| E0Z10_g10644 | E0Z10_g1045 | A0A4Z0Y319 | A0A4Z0YUH6 | 3'-5' exonuclease domain-containing protein. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.991 |
| E0Z10_g10644 | E0Z10_g2443 | A0A4Z0Y319 | A0A4Z0YR18 | 3'-5' exonuclease domain-containing protein. | DUF1767 domain-containing protein. | 0.983 |
| E0Z10_g10644 | E0Z10_g3076 | A0A4Z0Y319 | A0A4Z0Z2U0 | 3'-5' exonuclease domain-containing protein. | HRDC domain-containing protein. | 0.884 |
| E0Z10_g10644 | E0Z10_g3911 | A0A4Z0Y319 | A0A4Z0YMB2 | 3'-5' exonuclease domain-containing protein. | ERCC4 domain-containing protein. | 0.983 |
| E0Z10_g10644 | E0Z10_g4542 | A0A4Z0Y319 | A0A4Z0YK28 | 3'-5' exonuclease domain-containing protein. | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | 0.467 |
| E0Z10_g10644 | E0Z10_g4703 | A0A4Z0Y319 | A0A4Z0Z3E5 | 3'-5' exonuclease domain-containing protein. | Uncharacterized protein. | 0.937 |
| E0Z10_g10644 | E0Z10_g6291 | A0A4Z0Y319 | A0A4Z0YR54 | 3'-5' exonuclease domain-containing protein. | Uncharacterized protein. | 0.467 |
| E0Z10_g10644 | E0Z10_g7289 | A0A4Z0Y319 | A0A4Z0YSP7 | 3'-5' exonuclease domain-containing protein. | ERCC4 domain-containing protein. | 0.939 |
| E0Z10_g10644 | E0Z10_g9846 | A0A4Z0Y319 | A0A4Z0YMM3 | 3'-5' exonuclease domain-containing protein. | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | 0.989 |
| E0Z10_g10644 | SLX1 | A0A4Z0Y319 | A0A4Z0Z696 | 3'-5' exonuclease domain-containing protein. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. | 0.976 |
