SDK57815.1 protein (Glycomyces sambucus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

SDK57815.1

Dynamin family protein. (620 aa)

Predicted Functional Partners:

SDK57773.1

0.951

SDK57790.1

0.773

SDK85162.1

0.750

SDK57839.1

0.683

SDK57741.1

0.529

Your Current Organism:

Glycomyces sambucus

NCBI taxonomy Id: 380244
Other names: CGMCC 4.3147, DSM 45047, G. sambucus, Glycomyces sambucus Gu et al. 2007, Glycomyces sp. E71, JCM 15472, strain E71

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SDK57741.1	SDK57773.1	SAMN05216298_0626	SAMN05216298_0627	Potassium/proton antiporter, CPA1 family.	50S ribosome-binding GTPase.	0.529
SDK57741.1	SDK57790.1	SAMN05216298_0626	SAMN05216298_0628	Potassium/proton antiporter, CPA1 family.	Hypothetical protein.	0.529
SDK57741.1	SDK57815.1	SAMN05216298_0626	SAMN05216298_0629	Potassium/proton antiporter, CPA1 family.	Dynamin family protein.	0.529
SDK57741.1	SDK57839.1	SAMN05216298_0626	SAMN05216298_0630	Potassium/proton antiporter, CPA1 family.	Hsp70 protein; Belongs to the heat shock protein 70 family.	0.471
SDK57773.1	SDK57741.1	SAMN05216298_0627	SAMN05216298_0626	50S ribosome-binding GTPase.	Potassium/proton antiporter, CPA1 family.	0.529
SDK57773.1	SDK57790.1	SAMN05216298_0627	SAMN05216298_0628	50S ribosome-binding GTPase.	Hypothetical protein.	0.774
SDK57773.1	SDK57815.1	SAMN05216298_0627	SAMN05216298_0629	50S ribosome-binding GTPase.	Dynamin family protein.	0.951
SDK57773.1	SDK57839.1	SAMN05216298_0627	SAMN05216298_0630	50S ribosome-binding GTPase.	Hsp70 protein; Belongs to the heat shock protein 70 family.	0.689
SDK57790.1	SDK57741.1	SAMN05216298_0628	SAMN05216298_0626	Hypothetical protein.	Potassium/proton antiporter, CPA1 family.	0.529
SDK57790.1	SDK57773.1	SAMN05216298_0628	SAMN05216298_0627	Hypothetical protein.	50S ribosome-binding GTPase.	0.774
SDK57790.1	SDK57815.1	SAMN05216298_0628	SAMN05216298_0629	Hypothetical protein.	Dynamin family protein.	0.773
SDK57790.1	SDK57839.1	SAMN05216298_0628	SAMN05216298_0630	Hypothetical protein.	Hsp70 protein; Belongs to the heat shock protein 70 family.	0.678
SDK57815.1	SDK57741.1	SAMN05216298_0629	SAMN05216298_0626	Dynamin family protein.	Potassium/proton antiporter, CPA1 family.	0.529
SDK57815.1	SDK57773.1	SAMN05216298_0629	SAMN05216298_0627	Dynamin family protein.	50S ribosome-binding GTPase.	0.951
SDK57815.1	SDK57790.1	SAMN05216298_0629	SAMN05216298_0628	Dynamin family protein.	Hypothetical protein.	0.773
SDK57815.1	SDK57839.1	SAMN05216298_0629	SAMN05216298_0630	Dynamin family protein.	Hsp70 protein; Belongs to the heat shock protein 70 family.	0.683
SDK57815.1	SDK85162.1	SAMN05216298_0629	SAMN05216298_1662	Dynamin family protein.	Dynamin family protein.	0.750
SDK57839.1	SDK57741.1	SAMN05216298_0630	SAMN05216298_0626	Hsp70 protein; Belongs to the heat shock protein 70 family.	Potassium/proton antiporter, CPA1 family.	0.471
SDK57839.1	SDK57773.1	SAMN05216298_0630	SAMN05216298_0627	Hsp70 protein; Belongs to the heat shock protein 70 family.	50S ribosome-binding GTPase.	0.689
SDK57839.1	SDK57790.1	SAMN05216298_0630	SAMN05216298_0628	Hsp70 protein; Belongs to the heat shock protein 70 family.	Hypothetical protein.	0.678

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.69

expected number of edges:

14

PPI enrichment p-value:

0.000893

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033143

Regulation of intracellular steroid hormone receptor signaling pathway

4 of 29

2.32

2.84

2.95e-06

GO:0001889

Liver development

4 of 56

2.03

2.31

1.89e-05

GO:0031100

Animal organ regeneration

3 of 18

2.4

2.19

7.43e-05

GO:0035116

Embryonic hindlimb morphogenesis

3 of 20

2.36

2.14

8.87e-05

GO:0030858

Positive regulation of epithelial cell differentiation

3 of 26

2.24

1.99

0.00015

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016922

Nuclear receptor binding

7 of 79

2.13

4.54

6.80e-11

GO:0061629

RNA polymerase II-specific DNA-binding transcription factor binding

8 of 203

1.77

3.57

1.28e-10

GO:0003714

Transcription corepressor activity

6 of 134

1.83

3.0

5.54e-08

GO:0042975

Peroxisome proliferator activated receptor binding

3 of 7

2.81

2.75

8.75e-06

GO:0003712

Transcription coregulator activity

8 of 367

1.52

2.54

4.82e-09

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

6 of 358

1.4

1.52

5.96e-05

GO:0017053

Transcription repressor complex

3 of 49

1.97

1.29

0.0031

GO:0000785

Chromatin

5 of 432

1.24

0.95

0.0031

GO:0070847

Core mediator complex

2 of 19

2.2

0.93

0.0185

GO:0016592

Mediator complex

2 of 39

1.89

0.78

0.0332

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:31357699

(2019) MicroRNA Sequencing Reveals the Effect of Different Levels of Non-Fibrous CarbohydrateNeutral Detergent Fiber on Rumen Development in Calves.

3 of 18

2.4

1.7

0.00067

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11303

c4 zinc finger in nuclear hormone receptors, and Notch-HLH transcription pathway

4 of 27

2.35

2.56

1.19e-05

CL:26841

HNF-1, dimerization domain, and Zinc finger, nuclear hormone receptor-type

3 of 5

2.96

2.56

2.21e-05

CL:11305

Nuclear hormone receptor, and Nuclear receptor coactivator

2 of 17

2.25

0.87

0.0248

CL:9228

Core mediator complex, and Mediator complex

2 of 27

2.05

0.7

0.0489

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-400206

Regulation of lipid metabolism by PPARalpha

6 of 57

2.2

4.14

1.76e-09

MAP-383280

Nuclear Receptor transcription pathway

6 of 57

2.2

4.14

1.76e-09

MAP-9707564

Cytoprotection by HMOX1

5 of 61

2.09

3.16

2.13e-07

MAP-9711123

Cellular response to chemical stress

5 of 179

1.63

1.95

1.64e-05

MAP-350054

Notch-HLH transcription pathway

3 of 30

2.18

1.89

0.00022

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005654

Nucleoplasm

7 of 529

1.3

1.55

8.13e-06

GOCC:0000785

Chromatin

4 of 247

1.39

1.06

0.0029

GOCC:0016592

Mediator complex

2 of 25

2.08

0.91

0.0199

GOCC:0005634

Nucleus

11 of 2913

0.76

0.72

7.75e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0539

Nucleus

7 of 722

1.17

1.26

2.64e-05

KW-0805

Transcription regulation

4 of 200

1.48

1.26

0.0010

KW-0010

Activator

2 of 40

1.88

0.83

0.0261

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF15784

G-protein pathway suppressor 2-interacting domain

2 of 2

3.18

1.28

0.0049

PF10744

Mediator of RNA polymerase II transcription subunit 1

2 of 2

3.18

1.28

0.0049

PF04814

Hepatocyte nuclear factor 1 (HNF-1), N terminus

2 of 3

3.0

1.28

0.0049

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR044869

HNF-1, POU-specific (POUs) atypical domain

2 of 3

3.0

1.07

0.0120

IPR044866

HNF-1, dimerization domain

2 of 3

3.0

1.07

0.0120

IPR039066

Hepatocyte nuclear factor 1

2 of 2

3.18

1.07

0.0120

IPR031557

N-CoR, GPS2-interacting domain

2 of 2

3.18

1.07

0.0120

IPR023219

Hepatocyte nuclear factor 1, N-terminal domain superfamily

2 of 2

3.18

1.07

0.0120

(more ...)

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