node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHA_0819 | AHA_1681 | AHA_0819 | AHA_1681 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Protein of unknown function; Identified by match to protein family HMM PF04336. | 0.900 |
AHA_0819 | coaA | AHA_0819 | AHA_4039 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Pantothenate kinase; Identified by similarity to SP:P0A6I3; match to protein family HMM PF00485; match to protein family HMM TIGR00554. | 0.900 |
AHA_0819 | coaBC | AHA_0819 | AHA_0159 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.915 |
AHA_0819 | coaE | AHA_0819 | AHA_3872 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.908 |
AHA_1681 | AHA_0819 | AHA_1681 | AHA_0819 | Protein of unknown function; Identified by match to protein family HMM PF04336. | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | 0.900 |
AHA_1681 | coaA | AHA_1681 | AHA_4039 | Protein of unknown function; Identified by match to protein family HMM PF04336. | Pantothenate kinase; Identified by similarity to SP:P0A6I3; match to protein family HMM PF00485; match to protein family HMM TIGR00554. | 0.908 |
AHA_1681 | coaBC | AHA_1681 | AHA_0159 | Protein of unknown function; Identified by match to protein family HMM PF04336. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.900 |
AHA_1681 | coaD | AHA_1681 | AHA_0166 | Protein of unknown function; Identified by match to protein family HMM PF04336. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.902 |
birA | coaA | AHA_4040 | AHA_4039 | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Pantothenate kinase; Identified by similarity to SP:P0A6I3; match to protein family HMM PF00485; match to protein family HMM TIGR00554. | 0.530 |
birA | coaBC | AHA_4040 | AHA_0159 | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.473 |
birA | panC | AHA_4040 | AHA_3539 | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.548 |
coaA | AHA_0819 | AHA_4039 | AHA_0819 | Pantothenate kinase; Identified by similarity to SP:P0A6I3; match to protein family HMM PF00485; match to protein family HMM TIGR00554. | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | 0.900 |
coaA | AHA_1681 | AHA_4039 | AHA_1681 | Pantothenate kinase; Identified by similarity to SP:P0A6I3; match to protein family HMM PF00485; match to protein family HMM TIGR00554. | Protein of unknown function; Identified by match to protein family HMM PF04336. | 0.908 |
coaA | birA | AHA_4039 | AHA_4040 | Pantothenate kinase; Identified by similarity to SP:P0A6I3; match to protein family HMM PF00485; match to protein family HMM TIGR00554. | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.530 |
coaA | coaBC | AHA_4039 | AHA_0159 | Pantothenate kinase; Identified by similarity to SP:P0A6I3; match to protein family HMM PF00485; match to protein family HMM TIGR00554. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.930 |
coaA | coaD | AHA_4039 | AHA_0166 | Pantothenate kinase; Identified by similarity to SP:P0A6I3; match to protein family HMM PF00485; match to protein family HMM TIGR00554. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.930 |
coaA | coaE | AHA_4039 | AHA_3872 | Pantothenate kinase; Identified by similarity to SP:P0A6I3; match to protein family HMM PF00485; match to protein family HMM TIGR00554. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.454 |
coaA | panC | AHA_4039 | AHA_3539 | Pantothenate kinase; Identified by similarity to SP:P0A6I3; match to protein family HMM PF00485; match to protein family HMM TIGR00554. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.917 |
coaBC | AHA_0819 | AHA_0159 | AHA_0819 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | 0.915 |
coaBC | AHA_1681 | AHA_0159 | AHA_1681 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Protein of unknown function; Identified by match to protein family HMM PF04336. | 0.900 |