node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACG57061.1 | hisB | HY04AAS1_0371 | HY04AAS1_0373 | PFAM: DNA gyrase/topoisomerase IV subunit A; DNA gyrase repeat beta-propeller; KEGG: aae:aq_980 DNA gyrase A subunit. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: aae:aq_039 imidazoleglycerolphosphate dehydratase. | 0.792 |
ACG57061.1 | serS | HY04AAS1_0371 | HY04AAS1_0372 | PFAM: DNA gyrase/topoisomerase IV subunit A; DNA gyrase repeat beta-propeller; KEGG: aae:aq_980 DNA gyrase A subunit. | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). | 0.899 |
ACG57126.1 | hisA | HY04AAS1_0436 | HY04AAS1_0799 | KEGG: aae:aq_1155 ATP phosphoribosyltransferase regulatory subunit. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: aae:aq_1303 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.922 |
ACG57126.1 | hisB | HY04AAS1_0436 | HY04AAS1_0373 | KEGG: aae:aq_1155 ATP phosphoribosyltransferase regulatory subunit. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: aae:aq_039 imidazoleglycerolphosphate dehydratase. | 0.956 |
ACG57126.1 | hisC | HY04AAS1_0436 | HY04AAS1_1136 | KEGG: aae:aq_1155 ATP phosphoribosyltransferase regulatory subunit. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; Allinase-like; KEGG: sul:SYO3AOP1_1771 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.872 |
ACG57126.1 | hisD | HY04AAS1_0436 | HY04AAS1_0891 | KEGG: aae:aq_1155 ATP phosphoribosyltransferase regulatory subunit. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.932 |
ACG57126.1 | hisF | HY04AAS1_0436 | HY04AAS1_0445 | KEGG: aae:aq_1155 ATP phosphoribosyltransferase regulatory subunit. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.923 |
ACG57126.1 | hisG | HY04AAS1_0436 | HY04AAS1_0632 | KEGG: aae:aq_1155 ATP phosphoribosyltransferase regulatory subunit. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.999 |
ACG57126.1 | hisH | HY04AAS1_0436 | HY04AAS1_1383 | KEGG: aae:aq_1155 ATP phosphoribosyltransferase regulatory subunit. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.893 |
ACG57126.1 | hisI | HY04AAS1_0436 | HY04AAS1_0863 | KEGG: aae:aq_1155 ATP phosphoribosyltransferase regulatory subunit. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: aae:aq_1968 phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | ACG57126.1 | HY04AAS1_0799 | HY04AAS1_0436 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: aae:aq_1303 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | KEGG: aae:aq_1155 ATP phosphoribosyltransferase regulatory subunit. | 0.922 |
hisA | hisB | HY04AAS1_0799 | HY04AAS1_0373 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: aae:aq_1303 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: aae:aq_039 imidazoleglycerolphosphate dehydratase. | 0.986 |
hisA | hisC | HY04AAS1_0799 | HY04AAS1_1136 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: aae:aq_1303 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; Allinase-like; KEGG: sul:SYO3AOP1_1771 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.965 |
hisA | hisD | HY04AAS1_0799 | HY04AAS1_0891 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: aae:aq_1303 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.985 |
hisA | hisF | HY04AAS1_0799 | HY04AAS1_0445 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: aae:aq_1303 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | HY04AAS1_0799 | HY04AAS1_0632 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: aae:aq_1303 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.980 |
hisA | hisH | HY04AAS1_0799 | HY04AAS1_1383 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: aae:aq_1303 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | HY04AAS1_0799 | HY04AAS1_0863 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: aae:aq_1303 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: aae:aq_1968 phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisB | ACG57061.1 | HY04AAS1_0373 | HY04AAS1_0371 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: aae:aq_039 imidazoleglycerolphosphate dehydratase. | PFAM: DNA gyrase/topoisomerase IV subunit A; DNA gyrase repeat beta-propeller; KEGG: aae:aq_980 DNA gyrase A subunit. | 0.792 |
hisB | ACG57126.1 | HY04AAS1_0373 | HY04AAS1_0436 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: aae:aq_039 imidazoleglycerolphosphate dehydratase. | KEGG: aae:aq_1155 ATP phosphoribosyltransferase regulatory subunit. | 0.956 |