STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (391 aa)    
Predicted Functional Partners:
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 0.978
OBQ75458.1
Catalyzes the formation of methionine from L-homocysteine and S-adenosyl-L-methionine; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.925
OBQ74892.1
Methyltetrahydrofolate--corrinoid methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.923
OBQ74629.1
Methionine gamma-lyase; Catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.921
OBQ67854.1
Methionine adenosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the AdoMet synthase family.
  
  
 
0.905
OBQ62542.1
Conjugal transfer protein TraI; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.901
OBQ73407.1
GAF domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.901
glyA
Transcriptional regulator; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.823
guaA
Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.
 
  
 0.808
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
 
 
 0.796
Your Current Organism:
Mesorhizobium loti
NCBI taxonomy Id: 381
Other names: ATCC 700743, CCUG 27878, DSM 2626, IFO 14779, JCM 21464, LMG 6125, LMG:6125, M. loti, Mesorhizobium sp. LMG 6125, NBRC 14779, NZP 2213, Rhizobium loti
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