node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
OBQ61262.1 | fhs | A8146_17770 | A8146_28560 | Isocitrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. | 0.887 |
OBQ61262.1 | folD | A8146_17770 | A8146_16040 | Isocitrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.731 |
OBQ61262.1 | folD-2 | A8146_17770 | A8146_25660 | Isocitrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.537 |
OBQ70646.1 | OBQ74892.1 | A8146_26945 | A8146_03950 | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | Methyltetrahydrofolate--corrinoid methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.906 |
OBQ70646.1 | OBQ75458.1 | A8146_26945 | A8146_04040 | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | Catalyzes the formation of methionine from L-homocysteine and S-adenosyl-L-methionine; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.914 |
OBQ70646.1 | fhs | A8146_26945 | A8146_28560 | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. | 0.922 |
OBQ70646.1 | folD | A8146_26945 | A8146_16040 | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.932 |
OBQ70646.1 | folD-2 | A8146_26945 | A8146_25660 | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.932 |
OBQ70646.1 | glyA-2 | A8146_26945 | A8146_18350 | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.962 |
OBQ70646.1 | purH | A8146_26945 | A8146_14110 | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.917 |
OBQ70646.1 | purN | A8146_26945 | A8146_18455 | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.913 |
OBQ74892.1 | OBQ70646.1 | A8146_03950 | A8146_26945 | Methyltetrahydrofolate--corrinoid methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | 0.906 |
OBQ74892.1 | OBQ75458.1 | A8146_03950 | A8146_04040 | Methyltetrahydrofolate--corrinoid methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Catalyzes the formation of methionine from L-homocysteine and S-adenosyl-L-methionine; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
OBQ74892.1 | fhs | A8146_03950 | A8146_28560 | Methyltetrahydrofolate--corrinoid methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. | 0.945 |
OBQ74892.1 | glyA-2 | A8146_03950 | A8146_18350 | Methyltetrahydrofolate--corrinoid methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.918 |
OBQ74892.1 | purH | A8146_03950 | A8146_14110 | Methyltetrahydrofolate--corrinoid methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.900 |
OBQ74892.1 | purN | A8146_03950 | A8146_18455 | Methyltetrahydrofolate--corrinoid methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.900 |
OBQ75458.1 | OBQ70646.1 | A8146_04040 | A8146_26945 | Catalyzes the formation of methionine from L-homocysteine and S-adenosyl-L-methionine; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. | 0.914 |
OBQ75458.1 | OBQ74892.1 | A8146_04040 | A8146_03950 | Catalyzes the formation of methionine from L-homocysteine and S-adenosyl-L-methionine; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methyltetrahydrofolate--corrinoid methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
OBQ75458.1 | fhs | A8146_04040 | A8146_28560 | Catalyzes the formation of methionine from L-homocysteine and S-adenosyl-L-methionine; Derived by automated computational analysis using gene prediction method: Protein Homology. | Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. | 0.929 |