OBQ69950.1 protein (Mesorhizobium loti) - STRING interaction network

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Gene Fusion

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[Homology]

Score

OBQ69950.1

Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)

Predicted Functional Partners:

OBQ69949.1

0.986

OBQ68073.1

0.981

OBQ70396.1

0.981

OBQ64511.1

0.981

OBQ67276.1

0.979

OBQ67835.1

0.973

OBQ60194.1

0.972

OBQ74481.1

0.969

OBQ74925.1

0.964

OBQ63752.1

0.956

Your Current Organism:

Mesorhizobium loti

NCBI taxonomy Id: 381
Other names: ATCC 700743, CCUG 27878, DSM 2626, IFO 14779, JCM 21464, LMG 6125, LMG:6125, M. loti, Mesorhizobium sp. LMG 6125, NBRC 14779, NZP 2213, Rhizobium loti

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OBQ60194.1	OBQ69950.1	A8146_19715	A8146_29295	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.972
OBQ63752.1	OBQ69950.1	A8146_31115	A8146_29295	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.956
OBQ64511.1	OBQ69950.1	A8146_30900	A8146_29295	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.981
OBQ67276.1	OBQ69950.1	A8146_07185	A8146_29295	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.979
OBQ67835.1	OBQ69950.1	A8146_10355	A8146_29295	D-ala-D-ala transporter subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.973
OBQ68073.1	OBQ69950.1	A8146_11845	A8146_29295	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.981
OBQ69949.1	OBQ69950.1	A8146_29290	A8146_29295	Nickel ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.986
OBQ69950.1	OBQ60194.1	A8146_29295	A8146_19715	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.972
OBQ69950.1	OBQ63752.1	A8146_29295	A8146_31115	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.956
OBQ69950.1	OBQ64511.1	A8146_29295	A8146_30900	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.981
OBQ69950.1	OBQ67276.1	A8146_29295	A8146_07185	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.979
OBQ69950.1	OBQ67835.1	A8146_29295	A8146_10355	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	D-ala-D-ala transporter subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.973
OBQ69950.1	OBQ68073.1	A8146_29295	A8146_11845	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.981
OBQ69950.1	OBQ69949.1	A8146_29295	A8146_29290	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nickel ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.986
OBQ69950.1	OBQ70396.1	A8146_29295	A8146_27715	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.981
OBQ69950.1	OBQ74481.1	A8146_29295	A8146_01570	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.969
OBQ69950.1	OBQ74925.1	A8146_29295	A8146_04145	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.964
OBQ70396.1	OBQ69950.1	A8146_27715	A8146_29295	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.981
OBQ74481.1	OBQ69950.1	A8146_01570	A8146_29295	Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.969
OBQ74925.1	OBQ69950.1	A8146_04145	A8146_29295	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.964

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

28

PPI enrichment p-value:

1.32e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

7 of 25

2.0

3.95

5.53e-10

GO:0006352

DNA-templated transcription, initiation

3 of 15

1.85

1.41

0.0014

GO:0019438

Aromatic compound biosynthetic process

8 of 270

1.02

1.06

1.90e-05

GO:0018130

Heterocycle biosynthetic process

8 of 294

0.98

0.99

3.13e-05

GO:1901362

Organic cyclic compound biosynthetic process

8 of 305

0.97

0.96

3.63e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

4 of 6

2.37

2.73

5.59e-06

GO:0016987

Sigma factor activity

3 of 15

1.85

1.33

0.0021

GO:0003677

DNA binding

7 of 307

0.91

0.75

0.0010

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

4 of 9

2.2

2.71

3.94e-06

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37075846

(2023) Transcription regulation by CarD in mycobacteria is guided by basal promoter kinetics.

4 of 6

2.37

2.55

1.31e-05

PMID:38741736

(2024) Function of the RNA-targeting class 2 type VI CRISPR Cas system of Rhodobacter capsulatus.

3 of 3

2.55

2.0

0.00020

PMID:30200857

(2018) Transcriptional Responses to ppGpp and DksA.

4 of 14

2.0

1.99

9.46e-05

PMID:34254822

(2021) Promoter Architecture Differences among Alphaproteobacteria and Other Bacterial Taxa.

3 of 5

2.33

1.84

0.00034

PMID:24516534

(2014) Transcriptional profiling of nitrogen fixation and the role of NifA in the diazotrophic endophyte Azoarcus sp. strain BH72.

4 of 23

1.79

1.67

0.00027

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:215

RNA polymerase, and Transcription termination

3 of 5

2.33

1.63

0.00087

CL:92

Ribosome, and RNA polymerase

4 of 67

1.32

0.8

0.0141

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

rsp03020

RNA polymerase

4 of 4

2.55

3.46

2.66e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

7 of 66

1.57

2.47

6.05e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

4 of 9

2.2

2.63

5.88e-06

KW-0731

Sigma factor

3 of 15

1.85

1.51

0.00081

KW-0804

Transcription

7 of 150

1.22

1.43

5.88e-06

KW-0548

Nucleotidyltransferase

4 of 45

1.5

1.36

0.00055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04545

Sigma-70, region 4

3 of 7

2.18

1.52

0.0013

PF04542

Sigma-70 region 2

3 of 11

1.98

1.39

0.0019

PF00140

Sigma-70 factor, region 1.2

2 of 2

2.55

1.12

0.0091

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000943

RNA polymerase sigma-70

3 of 4

2.42

1.62

0.00096

IPR007630

RNA polymerase sigma-70 region 4

3 of 7

2.18

1.47

0.0016

IPR014284

RNA polymerase sigma-70 like domain

3 of 11

1.98

1.28

0.0033

IPR013325

RNA polymerase sigma factor, region 2

3 of 11

1.98

1.28

0.0033

IPR007627

RNA polymerase sigma-70 region 2

3 of 11

1.98

1.28

0.0033

(more ...)

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